卡介菌多糖核酸预防慢性阻塞性肺病急性加重的作用研究

目的：探讨卡介菌多糖核酸对慢性阻塞性肺病患者急性加重的预防作用及其机制。方法：将60例稳定期慢性阻塞性肺病患者随机分为治疗组和对照组，治疗组36例接受卡介菌多糖核酸0．5mg肌肉注射，日1次，共18次，二组患者均观察6个月，每两周门诊随访1次，进行临床情况评价，治疗组于治疗前，治疗后3个月及6个月检查血清IgA,IgG,IgM,CD3,CD4和CD8水平。结果：治疗组患者发生感染人数和感染天数均明显低于对照组（P＜0．05），治疗后患者血CD4及CD4／CD8比值明显升高（P＜0．05），结论：卡介菌多糖核酸通过增强细胞免疫功能，具有明显的预防慢性阻塞性肺病急性加重的作用。

The prophylactic effect of BCG polysaccharides nucleic acid on the acute attack of chronic obstructive pulmonary disease]

OBJECTIVE: To investigate the prophylactic effect of BCG polysaccharides nucleic acid (BCG-PSN) on patients with chronic obstructive pulmonary disease and inquire about the mechanism thereof. METHODS: Sixty patients with chronic obstructive pulmonary disease were divided into two groups. In the treatment group, 36 patients received BCG-PSN 0.5 mg intramuscular injection, quaque die alterna, for 18 times. All patients revisited the hospital every 2 weeks and were followed up for 6 months. The number and days of patients with acute attack in 3 and 6 months were assessed. In the treatment group, the blood samples were collected before treatment and 3 and 6 months after treatment for the measurement of the blood IgA, IgG, IgM, CD3, CD4 and CD8. RESULTS: The number and days of patients with acute attack in the treatment group were significantly lower than those in the control group. After the treatment by BCG-PSN, blood CD4 and CD4/CD8 were significantly increased. CONCLUSION: BCG-PSN increases the patient's cellular immunocompetence and thus serves as a good protection against the acute attack of chronic obstructive pulmonary disease.