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| 肺纤维化大鼠肺组织细胞间粘附分子-1表达的研究 | |
| 引用本文： | 范贤明,黄莉,李振华. 肺纤维化大鼠肺组织细胞间粘附分子-1表达的研究[J]. 泸州医学院学报, 2002, 25(1): 16-18 |
| 作者姓名： | 范贤明 黄莉 李振华 |
| 作者单位： | 1. 泸州医学院附属医院:呼吸内科,四川泸州,646000 2. 泸州医学院附属医院:干部病房,四川泸州,646000 3. 中国医科大学呼吸疾病研究所 |
| 摘 要： | 目的 :探讨细胞间粘附分子 - 1(ICAM - 1)在实验性肺纤维化大鼠肺组织中的表达及其作用。方法 :应用免疫组化ABC法结合显微图象分析 ,对博莱霉素 (BLM)致大鼠肺纤维化的慢性炎症过程中肺组织内ICAM - 1的表达进行了动态定量分布研究。结果 :气管内灌注BLM后第 1天肺泡上皮ICAM - 1表达即有增加 ,第 7天达高峰 ,第 2 8天仍持续高表达 ;支气管粘膜上皮、肺血管内皮及炎性细胞表面ICAM - 1表达也均有增加 ;且肺泡上皮I CAM - 1表达与肺组织炎症积分呈正相关。结论 :ICAM - 1参与了肺组织炎症和纤维化过程 |
| 关 键 词： | 细胞间粘附分子-1 肺纤维化 博莱霉素 |
| 文章编号： | 1000-2669(2002)01-0016-03 |
THE RESEARCH ON THE EXPRESSION OF ICAM-1 IN THE LUNGS OF RATS WITH BLM-INDUCED PULMONARY FIBROSIS |
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| Fan Xianming,et al. THE RESEARCH ON THE EXPRESSION OF ICAM-1 IN THE LUNGS OF RATS WITH BLM-INDUCED PULMONARY FIBROSIS[J]. Journal of Luzhou Medical College, 2002, 25(1): 16-18 | |
| Authors: | Fan Xianming et al |
| Affiliation: | Fan Xianming,et al Department of Respiratory,Luzhou Medical College Hospital |
| Abstract: | Objective: To evaluate the expression and the role of ICAM-1 in the lungs of rats with BLM-induced pulmonary fibrosis. Methods: The distribution and the quantity of ICAM-1 expression in rat lungs were determined by immunohistochemical and image analysis. Results: After intratracheal instillation of BLM, the expression of ICAM-1 on alveolar epithelium was increased on the 1st day, reached the peak on the 7th day, and remained the highest level on the 28th day. The expression of ICAM-1 on bronchus epithelium?microvascular epithelium?alveolar epithelium and inflammatory cells was also increased. In the meantime, the increased expression of ICAM-1 in the lungs was correlated with the inflammation degree in lung tissue. Conclusion: ICAM-1 in the lung probably took part in the formation of alveolitis and pulmonary fibrosis. |
| Keywords: | ICAM-1 Pulmonary fibrosis BLM |
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