乌司他丁治疗特重型颅脑损伤的临床疗效分析

①目的 探讨乌司他丁对特重型颅脑损伤的治疗效果。②方法 特重型颅脑损伤患者82例，随机分为观察组和对照组，均给予常规治疗，观察组给予乌司他丁治疗7天。分别于入院后1、3、7、14天进行GCS评分、应激性溃疡厦神经源性肺水肿发生率；于治疗后6个月评价治疗效果。③结果 观察组GCS评分，应激性溃疡及神经源性肺水肿的发生率比对照组明显改善；6个月后的观察组神经功能恢复水平明显优于对照组，病死率亦明显下降。④结论 乌司他丁能够有效地治疗特重型颅脑损伤，并可降低其并发症和改善预后。

Clinical research of ulinastatin in treatment of very severe craniocerebral injury

Objective To explore the therapeutic effect of the Ulinastatin on very severe craniocerebral injury. Methods 82 patients with very severe craniocerebral injury were divided into two groups - control group and treatment group treated with Ulinastatin for seven days. All patients were given conventional therapy and their GCS score, stress ulceration, neurogenic pulmonary edema were observed on 1,3,7,14 d after entering hospital. The therapeutic results were evaluated after six months. Results Compared with control group, the incidences of GCS score, stress ulceration and neurogenic pulmonary edema in treatment group were obviously improved. The level of function recovery after 6 months in treatment group was better than that in control group and the mortality in treatment group was obviously decreased. Conclusion Very severe craniocerebral injury can be treated by Ulinastatin,its complication was cut down and prognosis was improved effectively.