直肠癌草酸铂＋氟尿嘧啶＋亚叶酸钙方案时辰化疗临床分析

目的 评价草酸铂（L—OHP）联合亚叶酸钙（CF）和氟尿嘧啶（5-Fu）时辰化疗方案治疗直肠癌近期疗效和毒副作用。方法 60例直肠癌患者，其中时辰化疗组32例，对照组28例，时辰化疗组给予L—OHP 150mg／m^2，d1；10：00～16：00，CF 100mg／m^2，d1-5，22：00～24：00；5-Fu 500mg／m^2，d1-5，24：00～10：00。对照组给予L-OHP 150mg／m^2，d1,9：00～12：00，CF100mg／m^2，d1-5，12：00～14：00，5-Fu500mg／m^2，d1-5，14：00～18：00，按WHO标准评价疗效和毒副作用。结果 时辰化疗组CR7例，PR11例，总有效率（CR＋PR）56．3％；对照组CR2例，PR7例，总有效率32．1％。结论 L—OHP联合CF和5-Fu时辰化疗方案治疗直肠癌疗效较高，安全性好，副作用小，值得进一步临床观察。

CIVCOMBINATION CHEMOTHERAPY WITH OXALIPLATIN COMBINED 5 - FLUOROURACIL OR CALCIUM FOLINATE ON RECTUM CARCINOMA

Objective To evaluate the near therapeutic effect and toxicity of civcombination with chemotherapy oxaliplatin(L-OHP),calcium folinate(CF) and 5-Fluorouracil(5-Fu) on rectum carcinoma.Methods 60 rectum carcinoma patients,of which the civcombination chemotherapy group were 32,with L-OHP 150mg/m,day 1,continues from 10Am to 4Pm;CF 100mg/m,day 1-5,continues from 10 Pm to 12 Pm;5-Fu 500mg/m2,day1-5,continues from 12 Pm to 10Am.The group of contrast were 28,used the methods: L-OHP 150mg/m,day 1,continues 9 Am to 12 Am;CF 100mg/m,day 1-5,continues 12 Am to 2 Pm,5-Fu 500mg/m,day 1-5,continues 2 Pm to 6 Pm.We evaluated the effects and side effects in accordance with WHO criteria.Results The civcombination chemotherapy group CR was 7,PR was 11,the total effective rate(CR+PR) was 56.3%,and CR was 2,PR was 7 in the contrast group,the total effective rate(CR+PR) was(32.1)%.Conclusion The way to treat the rectum carcinoma by using LOHP and timing 5-Fu/CF is effective,safe and low toxicity.It deserves further clinical observation.