| 神经生长因子减轻新生大鼠缺氧缺血性脑损伤 |
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| 引用本文： | 徐放生,吴婉芳,林久治. 神经生长因子减轻新生大鼠缺氧缺血性脑损伤[J]. 中华儿科杂志, 1999, 37(6): 365-367 |
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| 作者姓名： | 徐放生 吴婉芳 林久治 |
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| 作者单位： | 首都儿科研究所 |
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| 摘 要： | 目的 观察神经生长因子对新生大鼠缺氧缺血性脑损伤的保护作用。方法 对５４只７日龄Ｗｉｓｔａｒ大鼠随机分为ＮＧＦ治疗组和对照组,缺氧缺血后即刻腹腔内注射ＮＧＦ或生理盐水。４４小时后测定各组脑含水量,２８天后测量各组脑重量并观察脑大体改变和组织学改变。
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| 关 键 词： | 神经生长因子 脑缺氧 脑缺血 新生儿 |
Protective effect of nerve growth factor on hypoxicischemic encephalopathy in newborn rats |
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| XU Fangsheng,WU Wanfang,LIN Jiuzhi Capital Institute of Pediatrics,Beijing. Protective effect of nerve growth factor on hypoxicischemic encephalopathy in newborn rats[J]. Chinese journal of pediatrics, 1999, 37(6): 365-367 |
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| Authors: | XU Fangsheng WU Wanfang LIN Jiuzhi Capital Institute of Pediatrics Beijing |
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| Affiliation: | XU Fangsheng,WU Wanfang,LIN Jiuzhi Capital Institute of Pediatrics,Beijing 100020 |
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| Abstract: | Objective To evaluate protective effect of nerve growth factor (NGF) on hypoxicischemic encephalopathy in newborn rats Methods Wistar rats of 7day old were divided randomly into NGFtreated and control groups Right after hypoxicischemic insult, NGF or normal saline solution were injected intraperitoneally Brain water contents in 44 hours and brain weights in 28 days were examined Macro and microscopical changes were observed Results Left brain water contents were (89215)% and (89913)%, respectively for NGF and control groups (P> 005) Left brain atrophy in NGF group was about 587% less than those in control group Macro and microscopical changes were less extensive in NGF group than those in control group Conclusion NGF could reduce longterm brain damages after hypoxicischemic insult but not brain edema |
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| Keywords: | Nerve growth factorsCerebral anoxiaCerebral ischemiaInfant newborn |
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