妊娠相关血浆蛋白A、高敏C反应蛋白与冠脉再狭窄的关系

目的：探讨妊娠相关血浆蛋白A（PAPP—A）。高敏C反应蛋白（hs—CRP）与经皮冠状动脉介入治疗（PCI）术后再狭窄的关系。方法：选择71例接受PCI治疗并于PCI术后6个月复查冠脉造影的患者，经冠脉造影证实出现支架内再狭窄的患者14例（再狭窄组），未出现再狭窄的患者57例（无再狭窄组），测定入选患者PCI术前和术后血浆PAPP-A，hs—CRP水平并分析其支架内再狭窄情况。结果：再狭窄组患者术后血浆PAPP—A，hs—CRP水平较无再狭窄组显著升高（P〈0．01），且术后PAPP—A，hs—CRP水平与PCI术后冠脉后期内径丢失指数呈正相关（r＝0．57，P〈0．01）。结论：PCI术后血浆PAPP-A，hs—CRP水平可以预测冠脉再狭窄的发生。

Correlation of pregnancy-associated plasma protein-A and high sensitivity C-reactive protein with restenosis after percutaneous coronary intervention

Objective： To investigate the relationship between plasma pregnancy-associated plasma protein-A （PAPP -A）, high sensitivity C- reactive protein （hs- CRP） and restenosis after percutaneous coronary intervention （PCI）. Methods： A total of 71 patients performed PCI and followed by repeated angiography 6 months after PCI were selected. Their baseline and follow-up angiograms were compared by quantitative coronary angiography to assess incidence of restenosis. They were assigned in restenosis group （n= 14） and no restenosis group （n= 57） by angiography. Plasma PAPP--A and hs-CRP were measured before and after PCI. Results： The level of plasma PAPP--A and hs--CRP in restenosis group were significantly higher than that in no restenosis group after PCI （P〈0.01）. The later loss index of coronary artery lumen diameter was positive correlated with plasma PAPP--A and hs--CRP after PCI （r=0.57, P〈0.01）, Conclusion： Plasma PAPP--A and hs--CRP level after PCI possibly forecasts the occurrence of restenosis after PCI.