血源性颅面转移瘤动物模型及磁共振观察

目的 介绍建立血源性颅面转移瘤动物模型的方法。分析成瘤率的影响因素。方法 ４３只新西兰大白兔从颈动脉接种ＶＸ２约１０＾８／ｍｌ瘤细胞，术后１周开始在不同时间行ＭＲＩ检查（平扫和增强扫描）。病理取材ＨＥ染色光镜下观察。结果 面部及眶内球后成瘤率分别为８１％及６７％。ＭＲＩ表现为Ｔ１ＷＩ略高信号，Ｔ２ＷＩ中高信号，Ｔ１ＷＩＧｄ－ＴＤＰＡ扫描肿瘤有增强效应。结论 上述方法制成的颅面部动物模型可为颅面部医

MRI Study and Production of Animal Model of Hematogenous Craniofacial Metastasis

Purpose The aims of this article are to introduce a hematogenous animal metastasis model and to analyse the affect factors of the rate of regrowth. Methods 43 New|zealand white rabbits are inoculated VX2 tumor cells.MRI plain scans and enhanced scans are taken at different times after inoculating VX2 1 week.Pathological study is made under microscope by HE stains. Results The rate of regrowth is 81% craniofacial,67% intraorbit metastasis.MRI showed the tumor hyper|or isointense on T 1WI,iso| or hyperintense on T 2WI and enhancement pattens after intravenous injection Gd|DTPA. Conclusion The animal model is able to provide a good method for craniofacial medical imaging and for other department study. [