INTESTINAL FLORA OF PATIENTS WITH RHEUMATOID ARTHRITIS: INDUCTION OF CHRONIC ARTHRITIS IN RATS BY CELL WALL FRAGMENTS FROM ISOLATED EUBACTERIUM AEROFACIENS STRAINS |
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| Authors: | SEVERIJNEN, A. J. KOOL, J. SWAAK, A. J. G. HAZENBERG, M. P. |
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| Affiliation: | Department of Immunology, Erasmus University Rotterdam P. O. Box 1738, 3000 DR Rotterdam, The Netherlands
* Departnent of Rheumatology, Dr Daniel den Hoed Clinic Rotterdam, The Netherlands |
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| Abstract: | The composition of the obligate anaerobic intestinal flora ofpatients with rheumatoid arthritis (RA) differed from that ofhealthy subjects (HS). Total numbers of aerobes as well as anaerobiccoccoid rods were found elevated when compared with HS. Eubacteriumspecies were found in all stool samples of both groups; Bifidobacteriumspecies were present in seven (RA) and eight (HS) out of 10subjects. From the flora of two RA patients and two HS Eubacteriumspecies were iso lated and identified. Cell wall fragments fromfour E. aerofaciens strains (two from RA, two from HS) weretested for arthritis induction in rats. All four strains inducedchronic arthritis which was histologically confirmed. We concludedthat in the normal intestinal flora of RA patients Eubacteriumspecies are present in high numbers (i.e. >109/g faeces);cell walls from isolated E. aerofaciens strains had arthropathicproperties. KEY WORDS: Arthritis, Faecal flora, Aerobes, Anaerobes, Coccoid rods, Eubacterium, Rat |
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