| 双试剂连续监测法测定血清丙氨酸氨基转移酶测量不确定度评定方法的研究 |
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| 引用本文： | 朱晓强,史咏梅,杨泽,谭华,刘军卫,朱玉兰,唐明慧,叶立青,莫秋华. 双试剂连续监测法测定血清丙氨酸氨基转移酶测量不确定度评定方法的研究[J]. 中国国境卫生检疫杂志, 2012, 0(6): 361-364 |
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| 作者姓名： | 朱晓强 史咏梅 杨泽 谭华 刘军卫 朱玉兰 唐明慧 叶立青 莫秋华 |
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| 作者单位： | 珠海市质量计量监督检测所;珠海出入境检验检疫局;珠海市人民医院;深圳出入境检验检疫局 |
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| 基金项目： | 国家质检总局科研基金项目(2008IK205) |
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| 摘 要： | 目的探讨临床检验中连续监测法测定中血清丙氨酸氨基转移酶（ALT）测量不确定度的评定方法。方法采用连续监测法在全自动生化分析仪上测定血清样本ALT的含量,据此原理建立数学模型,进行速率法测定血清中ALT的不确定度分析。结果血清中ALT的扩展不确定度U=4.8 U/L,k=2。结论本研究中分析了仪器本身和检测过程的几个不确定度分量,为进一步分析提供了一些思路。
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| 关 键 词： | 临床化学 测量不确定度 全自动生化分析仪 连续监测法 |
Study on the uncertainty assessment measurement of alanine aminotransferase by double reagent continuous monitoring method |
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| Affiliation: | ZHU Xiao-qiang*,SHI Yong-mei,YANG Ze,TAN Hua,LIU Jun-wei,ZHU Yu-lan,TANG Ming-hui,YE Li-qing,MO Qui-hua *Zhuhai Supervision Testing Institute of Quality and Metrology,Zhuhai,Guangdong 519000,China |
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| Abstract: | Objective To explore the measurement uncertainty evaluation method of serum alanine aminotransferase （ALT） in clinical examination. Methods The content of ALT in the serum samples was detected by automatic biochemical analyzer by continuous monitoring method, and mathematical models was established to perform the uncertainty analysis to determine the ALT in serum. Results The serum ALT of the expanded uncertainty was U=4.8 U/ L,k=2. Conclusion Several components of proper uncertainty of machines and uncertainty of measurement process are considered in this research, which can provide some clues for further research. |
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| Keywords: | Clinical chemistry Measurement uncertainty Automatic biochemical analyzer Continuous monitoringmethod |
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