| 增殖诱导配体和B淋巴细胞刺激因子与B淋巴细胞恶性肿瘤 |
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| 引用本文： | 李永胜,陈令松. 增殖诱导配体和B淋巴细胞刺激因子与B淋巴细胞恶性肿瘤[J]. 白血病．淋巴瘤, 2010, 19(2): 126-128. DOI: 10.3760/cma.j.issn.1009-9921.2010.02.026 |
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| 作者姓名： | 李永胜 陈令松 |
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| 作者单位： | 徐州医学院第二附属医院血液科,221006 |
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| 摘 要： | 肿瘤坏死因子超家族成员增殖诱导配体（APRIL）与B淋巴细胞刺激因子（BlyS）具有较高的同源性。近年来，APRIL／BlyS及其共同受体B细胞成熟抗原（BCMA）和穿膜蛋白活化物（TACI）双受体-双配体系统受到广泛重视。现就APRIL／BlyS及BCMA／TACI双受体-双配体结构、功能及其与B淋巴细胞恶性肿瘤间关系的最新研究进展作简要综述。
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| 关 键 词： | B淋巴细胞 淋巴瘤 多发性骨髓瘤 研究 |
| 收稿时间： | 2009-10-21; |
APRIL/BlyS and B-cell malignancies |
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| Yong-Sheng LI,Ling-Song CHEN. APRIL/BlyS and B-cell malignancies[J]. Journal of Leukemia & Lymphoma, 2010, 19(2): 126-128. DOI: 10.3760/cma.j.issn.1009-9921.2010.02.026 |
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| Authors: | Yong-Sheng LI Ling-Song CHEN |
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| Affiliation: | LI Yong-sheng, CHEN Ling-song. (Department of Hematology, the Second Affiliated Hospital of Xuzhou Medical College, Xuzhou 221006, China) |
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| Abstract: | There is a close homology between two related members of the TNF ligand superfamily:A proliferation-inducing ligand(APRIL)and B lymphocyte stimulator(BlyS).Recently,the double-receptors/double-ligands system which contains APRIL/BlyS and their collective receptors of BCMA and TACI has been attracting extensive attention.So the structure and functions of the double-receptors/double-ligands system,and association between them with B-cell malignancies will be reviewed based on latest researches. |
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| Keywords: | B-lymphocytes Lymphoma Multiple myeloma Research |
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