家族性白血病99例临床分析

目的探讨家族性白血病的临床特征和规律。方法收集国内1996～2006年文献26篇共99例家族性白血病病例进行统计分析。结果男女发病比例相近;绝大多数在中年以下年龄段发病;以父(母)子(女)、兄弟姐妹、祖孙之间发病常见;急性白血病占84.85%,慢性白血病占14.14%;化疗完全缓解率61.11%,其中急性白血病化疗完全缓解率62.25%。结论家族性白血病是一类家族或家族聚集性质的白血病,今后在积极开展家系调查,采取早期干预(监测和逆转)研究是努力的方向。

Clinical Analysis of 99 Cases with Familiar Leukemia

Objective To explore the clinical characteristic and regularity of familiar leukemia. Methods Collecting and analyzing statisticall, 26 national literatures about 99 cases with familiar leukemia from 1996 to 2006. Results There is no statistical difference of morbidity between male and female and most patients were under middle age; Familiar leukemia frequently occurred among parents and children, brother and sister, grand parents and grand children, and 84.85% were acute leukemia, 14.14% chronic leukemia, complete relieving rate after chemotherapy was 61.11%, among which the relieving rate of acute leukemia was 62.25%. Conclusion Family leukemia is a kind of disease concentrating in family. Genealogy investigation and early interference (surveillance and reversion) are the research direction.