HLA-DR antigens and phenotypes in Dutch coeliac children and their families |
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| Authors: | M. L. Mearin,,J. Bouquet,,N. Mourad,,E. Schoorel,,M. Sinaasappel,,I. Biemond,,G. M. Th.,Schreuder ,A. S. PEÑ A,H. H. van,Gelderen J. J. van,Rood |
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| Affiliation: | Departments of Gastroenterology, University Hospital, Leiden, The Netherlands;Departments of Pediatrics, University Hospital, Leiden, The Netherlands;Departments of Immunohaematology, University Hospital, Leiden, The Netherlands;Department of Pediatrics, Sophia Children's Hospital, Rotterdam, The Netherlands |
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| Abstract: | ![]()
In a study on the HLA-DR antigens and phenotypes in a series of Dutch coeliac children and their first-degree relatives, the B-cell antigens of 36 unrelated coeliac children, 110 first-degree relatives of 33 of them, and 201 controls were typed with the two-colour fluorescence test. The most frequent antigen was HLA-DR3 (69%), followed by DR7 (36%). The distribution of DR phenotypes showed that the most frequent was DR3/other DR (25%), followed by DR3/DR7 (17%), DR3/DR4 (14%), and DR3/DR3 (14%). However, due to the frequency of certain antigens in the controls, only phenotypes DR3/DR3 (relative risk = 6.2), DR3/DR7 (relative risk = 6.4), and DR3/DR4 (relative risk = 6.2) were significantly associated with CD. The family study confirmed the segregation of the disease with phenotypes DR3/DR3 and DR3/DR7. The present results show that the association between CD and phenotypes DR3/DR3 and DR3/DR7 is not an exclusive characteristic of Southern coeliac children. |
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| Keywords: | B-cell antigens coeliac disease DR antigens Dutch children HLA |
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