COX-2在急性髓细胞白血病中的表达和临床意义的初步研究

目的 探讨环氧化酶2（COX-2）基因在急性髓细胞白血病（AML）中的表达和意义及其对预后的影响。方法 采用Real time PCR检测AML患者中COX-2 mRNA的表达水平，分析COX-2表达水平与AML临床病理特征和预后的关系。采用Kaplan-Meier 法分析COX-2表达与总生存期（OS）的关系。结果 38例AML患者COX-2 mRNA相对表达量的均值为4.77±2.21，其中20例患者为COX 2高表达（8.33±1.96），18例患者为低表达（1.89±1.04）。COX-2表达与初诊白细胞计数和初次治疗反应有关，与性别和年龄无关。COX-2高表达者的中位OS为16.2个月，低于低表达者的25.6个月（P=0.041）。结论 COX-2表达水平与AML患者的生存有关，其高表达可能是AML的不良预后因素。

Expression and clinical significance of COX-2 expression in acute myeloid leukemia

Objective To investigate the expression and significance of cyclooxygenase-2 （COX-2） and evaluate its potential impact on the prognosis in acute myeloid leukemia（AML）. Methods The mRNA level of COX-2 in AML was detected by Real time- PCR. The relevance between COX-2 expression and clinical features of AML was assayed. The relation between COX-2 expression and overall survival （OS） was analyzed by Kaplan-Meier method. Results The average relative quantity of COX-2 mRNA in 38 AML pa- tients was 4. 77 ±2. 21, and among them, 20 patients were of high expression（8.33±1.96） , and 18 were of low expression （ 1.89 ± 1.04 ）. The expression of COX-2 was correlated with initial leukocyte count and the initial response to therapy, but not with gender and age. Furthermore, the median OS of patients with high expression of COX-2 was 16.2 months, shorter than 25.6 months of low expres- sion（ P = 0. 041 ）. Conclusion The expression of COX-2 in AML was associated with prognosis, and high expression of COX-2 may be a poor prognostic factor in AML.