Measuring the cone contribution to the ERG b-wave to assess function and predict anatomical rescue in RCS rats |
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Authors: | Pinilla I Lund R D Lu B Sauvé Y |
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Affiliation: | Moran Eye Center, Ophthalmology and Visual Sciences, University of Utah, 75 North Medical Drive, Salt Lake City, UT 84132, USA. |
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Abstract: | Subretinal injections of human retinal pigment epithelial (RPE) cells early in the course of retinal degeneration in Royal College of Surgeons (RCS) rats can rescue photoreceptors. Fourteen injected animals were studied using a double flash electroretinogram (ERG): 10 were examined longitudinally and four terminally with immunohistochemistry. The proportion of cone contribution to the ERG b-wave rather than the absolute size of isolated cone response proved to be a reliable indicator of function over time and a predictor of the proportion of cones identified anatomically in the area of optimal photoreceptor rescue. |
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Keywords: | RCS rat Retinal degeneration Cone Cell based therapy ERG double flash Pigmented Royal College of Surgeons rat, rdy+-p+ |
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