| 双氯芬酸钾喷雾剂抗炎镇痛的药效学研究 |
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| 引用本文： | 王梦,钱红美.双氯芬酸钾喷雾剂抗炎镇痛的药效学研究[J].中国现代应用药学,2004,21(5):365-367. |
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| 作者姓名： | 王梦 钱红美 |
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| 作者单位： | 江苏省药物研究所,江苏,南京,210009 |
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| 摘 要： | 目的观察双氯芬酸钾喷雾剂的抗炎镇痛作用.方法采用二甲苯致小鼠耳肿胀、角叉菜胶致大鼠足肿胀和小鼠热板法模型观察双氯芬酸钾喷雾剂的抗炎、镇痛作用.结果双氯芬酸钾喷雾剂对二甲苯致小鼠耳肿胀和角叉菜胶致大鼠足肿胀均有明显的抑制作用,并能增加热刺激小鼠的痛阈.结论双氯芬酸钾喷雾剂具有明显的抗炎、镇痛作用,作用强度与双氯芬酸二乙胺乳胶剂相似.
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| 关 键 词： | 双氯芬酸钾喷雾剂 抗炎 镇痛 |
| 文章编号： | 1007-7693(2004)05-0365-03 |
Anti-inflammatory and analgesic effects of diclofenac potassium spray |
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| WANG Meng,QIAN Hong-mei.Anti-inflammatory and analgesic effects of diclofenac potassium spray[J].The Chinese Journal of Modern Applied Pharmacy,2004,21(5):365-367. |
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| Authors: | WANG Meng QIAN Hong-mei |
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| Abstract: | OBJECTIVE To observe the anti-inflammatory and analgesic effects of diclofenac potassium spray. METHOD The effects were observed in the following models, xylene induced swelling of mouse ear, carrageenin induced paw edema in rat and hot-plate procedure in mice.RESULTS Diclofenac potassium spray was found to suppress ear swell induced by xylene in mice, inhibit paw edema induced by carrageenin in rat,and increase threshold of pain in mice. CONCLUSION Diclofenac potassium spray had significant anti-inflammatory and analgesic effects. The effects were similar to that of diclofenac diethylammon emulgel. |
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| Keywords: | diclofenac potassium spray anti-inflammation analgesia |
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