放射性125碘粒子近距离治疗20例中晚期恶性肿瘤近期疗效分析

目的探讨放射性125碘粒子组织间永久植入近距离治疗中晚期肿瘤的临床疗效。方法各种中晚期肿瘤20例采用组织间永久植入125碘粒子,在B超引导下或术中直视下植入粒子数3-70粒,活度14.8-25.9MBq/粒。植入术后1周内行X线或CT检查有无粒子迁移,在术后1个月行CT检查进行质量验证,在术后1、2、3、6个月后随访B超或CT,进行疗效评价。结果2个月后复查CT,近期总有效率85%。其中完全缓解（CR）15%（3/20）,部分缓解（PR）70%（14/20）,无变化（NC）10%（2/20）,进展（PD）5%（1/20）。治疗后随访至今（2-6个月）,所有治疗患者无一例出现由于放射治疗引起的并发症,患者的生存期在继续随访中。结论放射性125碘粒子组织间永久植入近距离治疗中晚期肿瘤的近期效果好,安全,副反应少,是一种新的治疗肿瘤手段。

The evaluation of short-term effect of Iodine-125 seed brachytherapy of middle-late stage cancer

Objective To discuss short-term effect of intraoperative Iodine-125 seed interstitial permanent implantation brachytherapy of middle-late stage cancer.Methods Iodine-125 seed interstitial permanent implantation for 20 cases middle-late stage cancer.Intraoperative Iodine-125 seed implantation guided by ultrasound,the activity of 125I per seed ranged from 14.8-25.9 MBq,the total number of sources implanter ranged from 3-70.All of the cases had routine chest X-ray or CT with in a week after implantation.The evaluation of post-implant quality was done with CT 1 month after implantation.To evaluate efficacy with ultrasound or CT one,two,three,six months after implantation.Results Total effective rate in short time was 85%,including CR(completely relieved)15%(3/20),PR(partial relieved)70%(14/20),NC(no respone)10%(2/20),PD(progressive disease)5%(1/20).Follow-up from two to six months,all of the cases had no comlications of radiotherapy.The lifetime continues to follow-up.Conclusions Short-term effect of intraoperative Iodine-125 seed permanent implantation brachytherapy of cancer have satisfying clinical effects,low morbidity and high efficacy,a new method of treatmemt cancer.