| 气相色谱法同时测定复方盐酸苯海拉明搽剂中2组分的含量 |
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| 引用本文： | 金英顺,郭建鹏,朴惠顺,黄海善. 气相色谱法同时测定复方盐酸苯海拉明搽剂中2组分的含量[J]. 中国药房, 2005, 16(9): 699-700 |
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| 作者姓名： | 金英顺 郭建鹏 朴惠顺 黄海善 |
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| 作者单位： | 1. 吉林延边大学医学院附属医院药剂科,延吉市,133000
2. 吉林延边大学药学院,延吉市,133000 |
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| 摘 要： | 目的建立以气相色谱法同时测定复方盐酸苯海拉明搽剂中樟脑和薄荷脑含量的方法。方法色谱柱为DB-WAX毛细管柱,柱温采取程序升温,进样口及检测器温度为250℃,载气为氮气,流速为1ml/min,分流比为25∶1,内标为正辛醇。结果樟脑、薄荷脑检测浓度线性范围分别为0.1～1.2mg/ml(r=0.9998)、0.2～1.2mg/ml(r=0.9999),平均回收率分别为98.78%、97.88%。结论本方法简便、准确、专属性强、重现性好,可用于复方盐酸苯海拉明搽剂的质量控制。
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| 关 键 词： | 气相色谱法 搽剂 樟脑 薄荷脑 含量测定 |
| 文章编号： | 1001-0408(2005)09-0699-02 |
| 修稿时间： | 2004-08-19 |
Simultaneous Determination of 2 Ingredients in Compound Diphenhydramine Liniment by GC |
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| JIN Yingshun,GUO Janpeng,PIAO Huishun,HUANG Haishan. Simultaneous Determination of 2 Ingredients in Compound Diphenhydramine Liniment by GC[J]. China Pharmacy, 2005, 16(9): 699-700 |
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| Authors: | JIN Yingshun GUO Janpeng PIAO Huishun HUANG Haishan |
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| Abstract: | OBJECTIVE:To establish the method for simultaneous determination of camphor and menthol in compound diphenhydramine liniment.METHODS:The DB-WAX capillary column was used.The column temperature was increased by programming with the sample entrance and detector being at250℃.The carrier gas was nitrogen.The flow rate was1ml/min and shunting ratio was25∶1.N-octyl alcohol was used as internal standard.RESULTS:The determinable concentrations of camphor and menthol were in the linear range of0.1～1.2mg/ml(r=0.9998)and0.2～1.2mg/ml(r=0.9999)respective-ly.The average recoveries were98.78%and97.88%respectively.CONCLUSION:The established method is accurate,spe-cific and replicable,which can be applied to quality control of the liniment. |
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| Keywords: | Gas chromatography Liniment Camphor Menthol Content determination |
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