腹腔注入乳酸钠林格液对大鼠肝肾血流动力学的影响

目的:探讨腹腔介质增强超声显像技术安全性,为其临床应用提供一定的实验性依据。方法:健康SD大鼠50只,雌雄各半,随机分为5组,A组:正常对照组;B、C、D、E组分别为腹腔注入乳酸钠林格液后10 min组、1 h组、24 h组及7 d组。对5组大鼠分别进行超声检测:测量肝脏门静脉(PV)的内径,监测肝门静脉最高流速(Vmax)、肝固有动脉(HA)的收缩期血流峰值速度(Vmax)、舒张末期血流速度(Vmin)、阻力指数(RI);肾主、肾段动脉的收缩期峰值血流速度(Vmax)、舒张末期血流速度(Vmin)、阻力指数(RI)等。结果:各实验组与正常对照组比较:超声监测大鼠肝脏PV内径及各项血流动力学指标差异无显著性意义(P>0.05);各实验组与正常对照组比较:肾脏血流动力学各项指标差异亦无显著性意义(P>0.05)。结论:腹腔注水成像技术是一种较为安全的超声增强显像技术。

Hepatic and renal hemodynamics affected by sodium lactate ringer''''s injection in rats

Objective:To evaluate the safety by using intra-abdominal medium enhancement in ultrasonic imaging technology.Methods:Fifty healthy SD rats were randomly divided into group A(normal control group),B,C,D and E.Group B,C,D and E were injected with sodium lactate ringer′s injection into abdominal cavity of the animals for the test of after 10min,1 h,24 h and 7 days,respectively.The rats in 5 groups were singly examined by ultrasonography for measuring the internal diameter and maximum flow of hepatic portal venous,peak blood flow volume in systolic phase,minimum velocity at end-diastolic phase and resistant index of hepatic artery,and the measurement was done on aorta and segmental renal artery.Results: The hepatic and renal hemodynamic indexes of all experimental groups showed no significant difference compared with control group(P>0.05).Conclusion Intra-abdominal medium enhancement in ultrasonic imaging technology can be safe in clinic.