Characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates in China |
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| Authors: | Sun Zhaogang Chao Yanjie Zhang Xuxia Zhang Jianyuan Li Yan Qiu Yunqing Liu Yi Nie Lihui Guo Aizhen Li Chuanyou |
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| Affiliation: | Department of Bacteriology and Immunology, Beijing Tuberculosis & Thoracic Tumor Research Institute, Tongzhou District, Beijing, China. |
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| Abstract: | Thirteen extensively drug-resistant tuberculosis isolates which were highly resistant to a broad spectrum of antituberculosis drugs were identified from 1,926 clinical isolates in China. They had highly diverse mycobacterial interspersed repetitive-unit-variable-number tandem-repeat patterns. Most, but not all, of the drug target genes had mutations contributing to resistance to the corresponding drug. |
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