In-vitro acid production by the oral bacterium Streptococcus mutans 10449 in various concentrations of glucose, fructose and sucrose |
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| Authors: | R Duguid |
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| Affiliation: | 1. Institute for Maternal and Child Health, IRCCS ‘Burlo Garofolo'', Trieste, Italy;2. Division of Oral Medicine and Pathology, Dental Science Department, University of Trieste, Trieste, Italy;3. Department of Haematology, Ospedale Maggiore, Trieste, Italy;4. Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy;1. Division of Aging and Geriatric Dentistry, Department of Oral Function and Morphology, Tohoku University Graduate School of Dentistry, Sendai, Japan;2. Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Japan;3. Division of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan;4. Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan;5. Division of Epidemiology, Department of Health Informatics and Public Health, Tohoku University School of Public Health, Graduate School of Medicine, Sendai, Japan;6. Department of Social Welfare, Faculty of General Welfare, Tohoku Fukushi University, Sendai, Japan;1. University of Michigan, Ann Arbor, MI, USA |
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| Abstract: | At intermediate and high concentrations, the results with the sugars were similar, with lactic acid as the main end product. Over 4 h, the pH fell from approx. 7 to 4. At low monosaccharide concentrations (2 mM glucose, 2 and 5 mM fructose), after an initial pH drop and period of lactic-acid production, evidence of pH rise and lactic-acid consumption were noted. This did not happen when sucrose was added to the bacteria. There was evidence of a heterolactic-acid fermentation pattern at low-sugar concentrations, lactic, acetic and formic acids being produced in similar amounts. The results suggest that, when low-sugar concentrations are present in dental plaque, Strep. mutans is capable of consuming previously-formed lactic acid. |
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