血清腹水白蛋白梯度与门脉高压性腹水的关系研究

目的研究血清腹水白蛋白梯度(SAAG)与门脉高压性腹水的关系.方法研究47例肝硬化腹水患者(均有门脉高压),比较不同Child分级的患者其血清腹水白蛋白梯度(SAAG)有无差异,比较不同食管静脉曲张程度的患者其SAAG有无差异,研究SAAG与门脉压力升高程度的关系.结果三组不同Child分级的患者其血清腹水白蛋白梯度(SAAG)无差异(P＞0.05).SAAG与血清白蛋白相关(r=0.478,P=0.001),SAAG与血清总胆红素及凝血酶原时间无关(均P＞0.05).三组不同食管静脉曲张程度的患者其SAAG无差异(P＞0.05).SAAG与门脉压力升高的程度无关(r=-0.140,P=0.649).结论SAAG并不能完全反映食管静脉曲张程度及门脉压力升高的程度,SAAG与肝功能受损程度无关.

Study of the serum-ascites albumin gradient and portal hypertensive ascites

Objective:To study the relationship of serum-ascites albumin gradient(SAAG)and the portal hyper-tensive ascites.Methods:Our study included47patients with liver cirrhosis,all patients have portal hypertension.Compare the level of SAAG among three groups of different degree of impairment of liver function determined by the Child-Pugh's score.And compared the level of SAAG among three groups of different grade of esophageal varices.Studied the correlation between the level of SAAG and the portal venous pressure.Results:There was no difference of the level of SAAG among three groups of different degree of impairment of liver function(P>0.05).The level of SAAG had correlation with the serum albumin(r=0.478,P=0.001).There was neither relationship between the SAAG and the serum total bilirubin(P>0.05),nor the SAAG and the prothrombin time(P>0.05).There was no dif-ference of the level of SAAG among three groups of different grade of esophageal varices(P>0.05).The level of SAAG had no correlation with the level of portal venous pressure(r=-0.140,P=0.649).Conclusions:The level of SAAG does not reflect the grade of esophageal varices and the level of portal venous pressure.The level of SAAG does not have any relationship with the degree of impairment of liver function.