前列腺偶发癌核仁组成区相关蛋白的检测

目的：探讨核仁改变在前列腺癌诊断和鉴别诊断中的意义。方法：应用胶银染色技术对核仁组成区相关嗜银蛋白（ＡｇＮＯＲ）进行观察，并用测微器测量核仁的最大横径和直径。结果：２０例前列腺癌核仁平均面积５．９８６±２．３５８μｍ，核仁最大直径３．１μｍ，且有６％左右畸形。增生组核仁平均面积为１．８６６±０．２４５μｍ，对两组数值进行ｔ检验，差异有非常显著意义。结论：揭示ＡｇＮＯＲ检测有助于区分前列腺良、恶性疾病，并可作为前列腺癌分级的一项指标。

The nucleolar organizer region related protein detection in the accidental prostate carcinoma

Objective To evaluate the nucleolar organizer region changes in the diagnosis and differental diagnosis of accidental prostate carcinoma. Method The nucleolar organizer region AgNORs were comparatively studied in 30 benign prostate hyperplasia and 20 accidental prostate carcinoma samples by means of colloidal silver stain and micrometer for measuring the maximal mecleolar diameter and crossyard. Results The average necleolar organizer region area sizes were 5.986±2.358μm, the maximal necleolar diameter was 3. 1μm in 20 cases of accidental prostate carcinoma, and there were almost 6% malformation. The necleolar organizer region area sizes were 1.866 ±0. 245μp. There was significant difference of necleolar organizer region AgNORs in BPH and accidental prostate carcinoma. Conclusion The results suggest that the necleolar organize nylon AgNORs detection was helpful for differental diagnosis in prostate diseases, It might be a valuble marker in prostate carcinoma classification.