Effect of acetylsalicylic acid on renal function in systemic lupus erythematosus |
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Authors: | S. Rasmussen J. Petersen I. L. Nielsen P. Christensen T. Hilden |
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Affiliation: | (1) Medical Department C, Diakonissestiftelsen, Medical Department TA, Rigshospitalet and the University Institute for Experimental Medicine, Copenhagen, Denmark;(2) Department of Clinical Physiology, Glostrup Hospital, DK-2600 Glostrup, Copenhagen, Denmark |
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Abstract: | Summary Glomerular filtration rate (GFR;51Cr-EDTA clearance), serum creatinine concentration and urinary excretion of prostaglandins were measured in 8 patients with systemic lupus erythematosus (SLE) before and after 2 weeks of treatment with acetylsalicylic acid (ASA). ASA 65 mg/kg or up to 4 g/daily was given as a sustained release preparation. The serum salicylate concentration ranged from 0.3 to 1.6 mmol/l. Serum creatinine after 1 and 2 weeks and GFR after 2 weeks of ASA treatment showed no significant changes. There was a clearcut decrease in urinary excretion of prostaglandins PGE2 and PGF2 , by 44% and 50%, respectively. It is concluded that therapeutic doses of ASA do not cause deterioration of GFR in patients with SLE and normal or moderately reduced renal function. |
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Keywords: | acetylsalicylic acid prostaglandins lupus erythematosus renal function |
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