单纯疱疹病毒感染与冠心病急性心肌梗死的关系

目的　探讨单纯疱疹病毒 (HSV )感染与冠心病心肌梗死的关系。方法　测定 5 1例急性心肌梗死 (AMI)和 42例陈旧性心肌梗死 (OMI)及 3 1例冠脉造影正常者 (对照组 )的HSV 1抗体、C 反应蛋白 (CRP)、血脂水平。结果　AMI组HSV 1IgG阳性率及水平高于对照组 (P <0 .0 5 ) ,血HSV 1DNA检测结果与之吻合。校正冠心病危险因素前、后 ,HSV 1IgG阳性与AMI均有相关关系 (OR4.2 66,OR3 .3 2 1)。AMI组中HSV 1( +)组CRP、TC、LDL C高于HSV 1( -)组(均P <0 .0 5 ) ,并且IgG与CRP、TC、LDL C呈正相关。 结论　HSV 1感染与AMI之间存在明显的相关性 ,与血脂、CRP也存在相关性

Relation between herpes simplex virus Infection and acute myocardial infarction

Objective To investigate the correlations between Herpes simplex virus (HSV) infection and acute myocardial infarction(AMI). Methods specific antibodies and DNA to HSV-1were measured in 51 patients with AMI(AMI group),42 patients with old myocardial infarction (OMI group) and 31 normal controls (NC group) who had no angiographic evidence of coronary artery disease. Moreover, the changes and relationships between C-reative protein(CRP),serum lipids and HSV-1 infection were determined in the three groups.Results The prevalence of HSV-1 IgG antibody was associated with AMI(OR4.266).Adjustment for the major cardiovascular risk factors didn't attenuate this correlation(OR3.321). Those who were HSV-1 positive in the AMI group had significantly higher not only levels of total cholesterol(TC) and low density lipoprotein cholesterol(LDL-C) than those who were HSV-1 negative in the same group but also the level of CRP than those who were HSV-1 negative in the same group and those who were HSV-1 positive in the NC group and OMI group.Correlation analysis revealed that the average concentration of IgG antibody to HSV-1 was positively associated with the levels of CRP,TC and LDL-C in the HSV-1 positive patients of the AMI group. Conclusion There is a significant correlation between HSV-1 infection and AMI. HSV-1 infection is associated with serum lipids and C-reative protein.