Inhibitory effect of Thai plant extracts on P-glycoprotein mediated efflux |
| |
Authors: | Junyaprasert Varaporn Buraphacheep Soonthornchareonnon Noppamas Thongpraditchote Suchitra Murakami Teruo Takano Mikihisa |
| |
Affiliation: | Department of Pharmacy, Faculty of Pharmacy, Mahidol University, 447 Sri-Ayutthaya, Rajathavee, Bangkok 10400, Thailand. pyvbp@mahidol.ac.th |
| |
Abstract: | Curcuminoids from Curcuma longa L. and extracts of Psidium guajava L., Andrographis paniculata (Burm. f.) Nees, Phyllanthus emblica L. and Solanum trilobatum L. were investigated for their inhibitory effect on P-glycoprotein (P-gp) on the efflux transport of rhodamine 123 (Rho-123 ) in Caco-2 cells and rat ileum. Of the five tested samples, curcuminoids and an extract of P. guajava showed the highest inhibitory effect on P-gp mediated efflux of Rho-123 in Caco-2 cells. Additionally, they were found to have equal potential in inhibiting Rho-123 efflux transport from serosal to mucosal surfaces of the rat ileum. |
| |
Keywords: | P‐glycoprotein plant extract inhibition efflux Caco‐2 cells rat ileum |
本文献已被 PubMed 等数据库收录! |
|