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Smoking withdrawal, nicotine dependence and prepulse inhibition of the acoustic startle reflex
Authors:Veena Kumari  Jeffrey A. Gray
Affiliation:(1) Section of Cognitive Psychopharmacology, Department of Psychological Medicine, Institute of Psychiatry, University of London, De Crespigny Park, London SE5 8AF, UK, GB;(2) Department of Psychology, Institute of Psychiatry, University of London, De Crespigny Park, London SE5 8AF, UK, GB
Abstract:The present study examined the relationship between nicotine dependence as measured by the Fagerstrom Tolerance Questionnaire (FTQ) and prepulse inhibition (PPI) of the acoustic startle reflex measured after overnight smoking withdrawal in a non-clinical population of male smokers with no history of psychiatric disorders or drug/alcohol abuse. It was found that smokers who scored high (>median) on the FTQ showed significantly less PPI as compared to those scoring low (
Keywords:Prepulse inhibition  Acoustic startle reflex  Smoking withdrawal  Nicotine dependence
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