类风湿性关节炎患者补体、CRP及免疫球蛋白水平检测

目的检测并探讨类风湿性关节炎（RA）患者血清中补体（C3、C4）、C-反应蛋白（CRP）及免疫球蛋白水平（IgA、IgG、IgM）水平的变化及其对疾病的影响。方法采用速率散射比浊法检测60例RA患者与40例健康人血清C3、C4、CRP、IgA、IgG、IgM水平，比较30例RA患者治疗前后检测结果。结果RA患者血清中C3、CRP、IgA、IgG和IgM检测水平显著高于健康对照组（P〈0．01），补体C4明显高于健康对照组（P〈0．05），治疗后CRP检测水平显著低于治疗前（P〈0．01），而治疗前后C3、C4、IgA、IgG、IgM无显著变化（P〉0．05）。结论补体、CRP、免疫球蛋白均参与类风湿性关节炎的发病，CRP还参与类风湿性关节炎的发展过程，观察补体、CRP和免疫球蛋白水平变化对疾病的诊断、指导治疗和评价预后有重要意义。

Detection of serum complements,c-reaction protein and immunoglobulin in patients with rheumatoid arthritics

Objective To detect the levels of serum complements （C3,C4）,c-reaction protein （CRP） and immunoglobulin （IgA,IgG and IgM） in patients with rheumatoid arthritics （RA）. Methods The levels of C3,C4,CRP, IgA, IgG and IgM were detected with rale-nephelometry in patients. The results of 60 patients were compared with that of 40 healthy control. Results The levels of serum C3,CRP, IgA,IgG and IgM in RA patients were higher than that of healthy control, （P〈0.01）. The levels of serum C4 in RA patients were higher than in healthy control,（P〈0.05）. After treatment, the levels of CRP was significant decreased, （P〈0.01）, and there was no significant difference in levels of C3,C4, IgA,IgG and IgM （P〉0.05）. Conclusion The combined detection of complements,CRP and immunoglobulin in patients with rheumatoid arthritis is helpful for guidance of diagnosis and treatment of rheumatoid arthritis.