北京降压0号治疗原发性高血压75例临床研究

目的 探讨北京降压0号治疗原发性高血压的降压效果及安全性。方法 将150例在门诊就诊的轻、中度高血压患者随机分为两组，每组75例。北京降压0号治疗组用北京降压0号，1片／d;对照组用长效降压药拉西地平4mg／d。两组服药时间均为晨服。每周随访1次，追踪观察6个月，了解其降压效果及不良反应发生情况；并在治疗前后分别检测血糖、血脂、电解质及肝、肾功能变化。结果 用北京降压0号治疗1周、4周和8周后达到正常血压值（〈140／90mmHg）者分别为52例（69．33％）、64例（85．33％）和70例（94．66％）。用拉西地平片治疗1周、4周和8周后达到正常血压值者分别为56例（74．67％）、62例（82．67％）和69例（92．67％）。两组降压幅度与疗效无明显差异（P〉0．05）。用北京降压0号治疗出现不良反应5例（6．7％），主要为轻度头晕、鼻塞、乏力，继续治疗可自行缓解。对照组出现不良反应6例（8．0％），为头痛、面红、心悸和轻度浮肿。结论 应用北京降压0号可显著降低轻、中度高血压患者血压，安全性好，可作为临床推荐使用的高血压一线药物。

Treatment of Primary Hypertension with Beijing Jiangya 0 Hao

Objective To explore the effect and safety of Beijing jiangya 0 hao in treating primary hypertension. Methods Patients with mild and moderate primary hypertension were divided into two groups. One group was treated with Beijing jiangya 0 hao, one sheet a day, while the other group was treated with lacidipine 4 mg/d. Patients of both groups took drugs in the morning. Blood pressure and adverse response were monitored once a week for 6 months. Blood sugar, lipid, serum electrolure and renal function were detected before and after treatment. Result 52 patients (69.33%), 64 patients (85.33%) and 70 patients (94.66%) respectively restored normal blood pressure(<140/90mmHg) 1, 4 and 8weeks after treated with Beijing jiangya 0 hao. 56 patients (74.67%), 62 patients (82.67%) and 69 patients (92.67%) respectively restored normal blood pressure 1 ,4 and 8 weeks after treated with lacidipine. There was no significant difference of effect between two groups (P>0.05). 5 patients treated with Beijing jiangya 0 hao had adverse responses, mainly light dizziness, nasal obstruction and inertia. 6 patients of the control group had adverse responses, mainly headache, flushing, palpitation and light swollen. Conclusion Beijing jiangya 0 hao can safely decrease the blood pressure of the patients with mild and moderate hypertension. This should be a top listed drug for treating hypertension.