肝型脂肪酸结合蛋白在重症患者急性肾损伤早期诊断中的意义

目的:探讨尿肝型脂肪酸结合蛋白(L-FABP)在重症患者急性肾损伤(AKI)中的早期诊断价值。方法:以我院收治的危重症患者为观察对象，按照阿姆斯特丹AKI诊断标准，将5d内符合诊断标准的AKI患者纳入AKI组（12例），对照组（12例）由匹配的非AKI患者构成。每24 h收集尿标本，持续5d。ELISA法检测尿L-FA...

Value of Urine Liver-Type Fatty Acid Binding Proteins in the Early Diagnosis of Acute Kidney Injury in Critically Ill Patients

Objective: To investigate the value of urinary liver-type fatty acid binding proteins(L-FABP) in the early diagnosis of acute kidney injury(AKI) in critically ill patients.Methods: Critically ill patients were divided into the AKI group(n=12) and non-AKI group(n=12).Blood and urinary samples were collected daily for five days.The samples were used to determine serum creatinine(Scr),N-acetyl-β-D-glucosaminidase(NAG),as well as urinary L-FABP.Standard statistic analysis was used along with receiver operating characteristic curve analysis to evaluate the diagnose value.Results: There were no significant differences in clinical parameters between non-AKI(n=14) and AKI(n=12) groups.As compared with the levels obtained three days before the diagnosis of AKI,the urinary L-FABP levels in the AKI group increased significantly(P<0.05),while Scr and NAG levels had no changes two days or one day prior to the diagnosis of AKI(all P>0.05).The levels of urinary L-FABP,Scr and NAG had no significant changes in the control group(all P>0.05).Conclusion: Urinary L-FABP appears to be a sensitive and specific marker earlier than Scr,which may be a good biomarker for early diagnosis of AKI in critically ill patients.