| 细胞外信号调节激酶对细胞周期调控的影响 |
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| 引用本文： | 张贵斌,王伟,徐运兰,王萍,田代实. 细胞外信号调节激酶对细胞周期调控的影响[J]. 武汉大学学报(医学版), 2011, 32(6): 717-722 |
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| 作者姓名： | 张贵斌 王伟 徐运兰 王萍 田代实 |
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| 作者单位： | 1. 湖北医药学院附属襄阳医院神经内科 湖北襄阳441000
2. 华中科技大学同济医学院附属同济医院神经内科 湖北武汉430030 |
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| 基金项目： | 国家自然科学基金重点资助项目(编号:30230140) |
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| 摘 要： | 目的:研究脑缺血后细胞外信号调节激酶(ERK)对细胞周期调控的影响。方法:建立光化学法诱导大鼠局灶性脑缺血模型，随机分为脑缺血组（对照组及干预组）和假手术组。干预组于缺血前30 min尾静脉注入ERK阻滞剂U0126，对照组尾静脉注入相同体积不含U0126的DMSO稀释溶液。应用免疫组织荧光化学法观察细胞周期蛋白D1 ...
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| 关 键 词： | ERKs U0126 Cyclin D1 Cyclin E E2F 细胞周期 脑缺血 |
Effect of Extracellular Signal-Regulated Kinases on the Cell Cycle Regulation After Focal Cerebral Ischemia |
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| ZHANG Guibin,WANG Wei,XU Yunlan,WANG Ping,TIAN Daishi. Effect of Extracellular Signal-Regulated Kinases on the Cell Cycle Regulation After Focal Cerebral Ischemia[J]. Medical Journal of Wuhan University, 2011, 32(6): 717-722 |
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| Authors: | ZHANG Guibin WANG Wei XU Yunlan WANG Ping TIAN Daishi |
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| Affiliation: | ZHANG Guibin1,WANG Wei2,XU Yunlan2,WANG Ping2,TIAN Daishi2 1Dept.of Neurology,Xiangyang Hospital Affiliated to Hubei Medical University,Xiangyang 441000,Hubei,China 2Dept.of Neurology,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China |
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| Abstract: | Objective: To investigate the effect of extracellular signal-regulated kinases(ERKs) on cell cycle regulation after ischemia.Methods: Cerebral ischemic model was induced by photochemistry method.Animals were divided randomly into cerebral ischemia groups(control and U0126 treated groups) and sham group.Rats in U0126 treated group were subjected to ERK inhibitor U0126 injection at 30 min pre-ischemia through caudal veins,while rats in control group were subjected to identical volume of DMSO solution without ... |
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| Keywords: | Extracellular Signal Regulated Protein U0126 CyclinD1 CyclinE E2F Cell Cycle Cerebral Ischemia |
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