胃癌及癌前疾病血清细胞纤维连接蛋白的检测及其临床意义

目的:探讨胃癌及癌前疾病患者血清细胞纤维连接蛋白(cFN)含量在不同胃疾病中变化情况及临床意义,及与幽门螺杆菌(HP)感染的相关性。方法:利用酶联免疫吸附试验检测1177例正常人、癌前疾病及胃癌患者血清cFN含量、胃疾病患者血清HP抗体含量。结果:血清cFN含量胃癌组明显高于正常人及胃良性疾病组(P<0.05),分化不良组显著高于分化良好组(P<0.01),淋巴结转移阴、阳性组比较差异无显著性(P>0.05)。胃疾病患者血清HP抗体检测,血清cFN含量,HP阴、阳性组比较差异无显著性,但在胃良性病变组中HP抗体阳性组较阴性组高,而胃癌组HP抗体阳性组较阴性组低。结论:血清cFN含量测定可用于胃良恶性疾病的鉴别,对胃癌诊断具有潜在的临床应用价值;胃癌患者血清cFN含量与胃癌分化程度密切相关,与胃淋巴结转移无关。血清cFN含量HP抗体阴性、阳性组比较差异无显著性,但胃良性疾病组,HP抗体阳性组较HP阴性组略高,胃癌组,HP抗体阳性组较HP阴性组略低,提示HP感染在胃良性疾病阶段和胃癌阶段,对血清cFN含量可能具有不同影响。由于血清HP抗体与其HP感染不一定平行,HP感染对血清cFN含量的影响有待于进一步深入探讨。

Clinical Significance of Serum Cellular Fibronectin Concentrations in Gastric Cancer and Precancerous Diseases of Stomach

Objective:To investigate the clinical significance of cFN concentrations in gastric carcinoma and precancerous diseases of stomach,and the relationship between the serum cFN concentrations and HP infection.Methods:ELISA was used to detect the serum cFN concentrations in 1177 normal subjects,precancerous diseases of stomach and gastric cancer,and to detect the serum antibodies concentrations and anti-HP in all kinds of gastric diseases.Results:The median concentrations of the serum cFN of gastric cancer were significantly high than normal subjects and gastric benign diseases(P<0.05).There were significantly different between the differentiated gastric cancer and the undifferentiated gastric cancer and were not significantly different between the positive and negative groups of lymphatic metastasis.The difference of the serum cFN median concentrations was not significant between IG-HP negative group and IG-HP positive group in all kinds gastric diseases.But the serum cFN median concentrations of the IG-HP positive group were higher than the IG-HP negative group and gastric cancer group was opposite to the above results.Conclusions:The serum cFN concentrations had a clinically useful potential value for identification between gastric cancer and gastric precancerous diseases.The serum cFN concentrations were related with differentiated degree of gastric cancer and were no statistically significant with metastasis of lymphatic node.No statistical difference is found between the IG-HP negative and the HP positive group in all kinds of gastric diseases.But the serum cFN median concentration in IG-HP positive group is higher than in IG-HP negative group gastric benign diseases group,and gastric cancer group was opposite to the above result.It showed that HP played a difference role in the step of the gastric precancer diseases and gastric cancer,and this will be the focus of further studies.