| 食管鳞状细胞癌PLCE1基因多态性与吸烟、饮酒及体质量指数的相关性 |
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| 引用本文： | 宋昕,周福有,张连群,王建坡,王能超,张朋,杜娴娟,申芳芳,赵学科,王立东.食管鳞状细胞癌PLCE1基因多态性与吸烟、饮酒及体质量指数的相关性[J].河南大学学报(医学版),2012(3):186-190,202. |
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| 作者姓名： | 宋昕 周福有 张连群 王建坡 王能超 张朋 杜娴娟 申芳芳 赵学科 王立东 |
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| 作者单位： | 郑州大学第一附属医院河南省食管癌重点开放实验室;新乡医学院癌症研究中心;河南省安阳市肿瘤医院 |
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| 基金项目： | 国家科技部863重大项目(2012AA02A503);国家自然科学基金项目(81071783);河南省中原学者专项经费(2011) |
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| 摘 要： | 目的探讨食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)PLCE1基因多态性rs2274223位点与吸烟、饮酒、体质量指数的相关性。方法选取7 673例患者(汉族)和11 013例正常者PLCE1基因多态性rs2274223位点基因分型资料(基因分型采用Sequenom芯片),比较各组间基因型和等位基因频率的分布。结果病例组与对照组间PLCE1基因多态性rs2274223位点基因型和等位基因频率分布,差异有统计学意义(P<0.05),AG、GG基因型是ESCC的遗传危险因子。rs2274223在吸烟/不吸烟、饮酒/不饮酒及各级BMI人群中都与ESCC有相关性(P<0.05),但吸烟、饮酒、BMI对rs2274223的效应无明显影响。结论 PLCE1基因多态性、rs2274223遗传多态性与ESCC的易感性相关,但与吸烟、饮酒、体质量指数无明显相关性。
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| 关 键 词： | 食管鳞状细胞癌 遗传学 等位基因 PLCE1 |
Correlation of PLCE1 gene polymorphism in the smokers/non-smokers,drinking/non-drinking,and BMI subgroups with esophageal squamous cell carcinoma |
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| SONG Xin,ZHOU Fu-you,ZHANG Lian-qun,WANG Jian-po,WANG Neng-chao,ZHANG Peng,DU Xian-juan,SHEN Fang-fang,ZHAO Xue-ke,WANG Li-dong.Correlation of PLCE1 gene polymorphism in the smokers/non-smokers,drinking/non-drinking,and BMI subgroups with esophageal squamous cell carcinoma[J].Journal of Henan University,2012(3):186-190,202. |
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| Authors: | SONG Xin ZHOU Fu-you ZHANG Lian-qun WANG Jian-po WANG Neng-chao ZHANG Peng DU Xian-juan SHEN Fang-fang ZHAO Xue-ke WANG Li-dong |
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| Institution: | 1,2(1.Henan Key Laboratory for Esophageal Cancer Research,The First Affiliated Hospital,Zhengzhou University,Zhengzhou,Henan 450052,China;2.Cancer Research Center,Xinxiang Medical University,Xinxiang,Henan 453003,China;3.Anyang Tumor Hospital,Anyang,Henan 455000,China) |
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| Abstract: | Objective To correlate rs2274223 polymorphism within PLCE1 gene polymorphism in the smokers/non-smokers,drinking/non-drinking,and BMI subgroups with esophageal squamous cell carcinoma(ESCC).Methods The single nucleotide polymorphisms(SNPs) were genotyped by the Sequenom iPLEX Chips in 7673 cases and 11013 controls.The distribution of genotypes and allele frequencies were compared among subgroups.Results The genotype frequency of rs2274223 polymorphism within PLCE1 gene was of statistical significance between the cases and the controls(P<0.05).AG,GG are dangerous factor for ESCC.ESCC had significant association with smokers/non-smokers,drinking/non-drinking and BMI subgroups in SNP rs2274223(P<0.05).However,smoking,drinking,and BMI did not significantly alter the effect of SNP rs2274223.Conclusions The SNP rs2274223 polymorphism within PLCE1 gene was associated with the susceptibility of ESCC.However,smoking,drinking,and BMI did not significantly alter the effect of SNP rs2274223. |
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| Keywords: | esophageal squamous cell carcinoma genetic allele PLCE1 |
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