Creatine kinase in relation to body fat in a Caucasian overweight and obese population |
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| Authors: | Svein I. Bekkelund Rolf Jorde |
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| Affiliation: | 1. Department of Neurology and Neurophysiology, University Hospital of North Norway, Troms?, Norway;2. Department of Clinical Medicine, UiT – The Arctic University of Norway, Troms?, Norway;3. svein.ivar.bekkelund@unn.no;5. Department of Clinical Medicine, UiT – The Arctic University of Norway, Troms?, Norway;6. Division of Internal Medicine, University Hospital of North Norway, Troms?, Norway |
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| Abstract: | We investigated the association between serum creatine kinase (CK) and body fat mass in an overweight and obese population. In this cross-sectional study, 454 Caucasian overweight and obese individuals recruited from a medical outpatient clinic and via newspaper advertising underwent dual-energy X-ray absorptiometry (DEXA). Serum CK was obtained along with supplementary blood samples. This report is based on a secondary analysis from a previous randomized controlled trial treating obesity with vitamin D3. Serum CK correlated negatively with body fat mass in men (r?=??.18, p?=?.025) but not in women (r?=??.11, p?=?.069). An insignificant negative trend for logCK across quartiles of fat mass in men was found (p?=?.098). CK did not associate significantly with lean mass, but lean mass correlated positively with fat mass in both groups (p?p?=?.001). These data support the view that circulating CK interacts with obesity in a favourable way independent of its muscular connection in men. CK was not associated with fat mass in women. |
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| Keywords: | Obesity creatine kinase fat mass lean mass body composition |
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