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Urinary neutrophil gelatinase-associated lipocalin as a marker for disease activity in lupus nephritis |
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| Authors: | Mohamed S El Shahawy Mahmoud H Hemida Hafez A Abdel-Hafez Tarek Z El-Baz Abdel-Wahab M Lotfy Tarek M Emran |
| Institution: | 1. Department of Internal Medicine, Gastroenterology Unit, AL-Azhar University, Cairo, Egypt;2. Department of Internal Medicine, Immunology Unit, AL-Azhar University, Cairo, Egypt;3. Department of Internal Medicine, Nephrology Unit, AL-Azhar University, Cairo, Egypt;4. Department of Clinical Pathology, AL-Azhar University, Assiut, Egypt |
| Abstract: | The neutrophil gelatinase-associated lipocalin (NGAL) has been emerging as a novel biomarker of acute kidney injury while its value in lupus nephritis is uncertain. The aim of this study was to assess urinary NGAL levels as a marker for disease activity in patients with lupus nephritis.This study included 70 systemic lupus erythematosus (SLE) patients; 50 with active lupus nephritis (LN) and 20 without as well as 20 matched controls. The neutrophil gelatinase-associated lipocalin (NGAL) in both serum and urine samples was measured by enzyme-linked immunosorbent assay (ELISA). Patients with active LN received standard treatment then assessed for response as well as the value of urinary NGAL (uNGAL). Our results revealed that, The SLE patients with or without LN had an elevated urinary NGAL as compared to controls (p? |
| Keywords: | Neutrophil gelatinase-associated lipocalin (NGAL) systemic lupus erythematosus acute kidney injury lupus nephritis |