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Human umbilical cord blood stem cells and brain-derived neurotrophic factor for optic nerve injury:a biomechanical evaluation |
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| Authors: | Zhong-jun Zhang Ya-jun Li Xiao-guang Liu Feng-xiao Huang Tie-jun Liu Dong-mei Jiang Xue-man Lv Min Luo |
| Institution: | 1. Department of Mechanics, PLA Air Force Aviation University, Changchun, Jilin Province, China 2. Mathematics School, Jilin University, Changchun, Jilin Province, China 3. Department of 0phthalmology, China-Japan Friendship Hospital, Jilin University, Changchun, Jilin Province, China 4. Department of Pain, China-Japan Friendship Hospital, Jilin University, Changchun, Jilin Province, China |
| Abstract: | Treatment for optic nerve injury by brain-derived neurotrophic factor or the transplantation of human umbilical cord blood stem cells has gained progress, but analysis by biomechanical indicators is rare. Rabbit models of optic nerve injury were established by a clamp. At 7 days after injury, the vitreous body received a one-time injection of 50 μg brain-derived neurotrophic factor or 1 × 106 human umbilical cord blood stem cells. After 30 days, the maximum load, maximum stress, maximum strain, elastic limit load, elastic limit stress, and elastic limit strain had clearly improved in rabbit models of optical nerve injury after treatment with brain-derived neurotrophic factor or human umbilical cord blood stem cells. The damage to the ultrastructure of the optic nerve had also been reduced. These findings suggest that human umbilical cord blood stem cells and brain-derived neurotrophic factor effectively repair the injured optical nerve, improve biomechanical properties, and contribute to the recovery after injury. |
| Keywords: | nerve regeneration optic nerve injury human umbilical cord blood stem cells brain-derived neurotrophic factor biomechanical properties neural regeneration |
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