| CD28/CTLA-4:B7在特发性血小板减少性紫癜患者外周血淋巴细胞中的表达及意义 |
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| 引用本文： | 章圣辉,毕来喜,韩义香,吴建波,胡晓霞.CD28/CTLA-4:B7在特发性血小板减少性紫癜患者外周血淋巴细胞中的表达及意义[J].临床血液学杂志,2010(2). |
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| 作者姓名： | 章圣辉 毕来喜 韩义香 吴建波 胡晓霞 |
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| 作者单位： | 温州医学院附属第一医院内科实验室;温州医学院附属第一医院血液科; |
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| 摘 要： | 目的:探讨特发性血小板减少性紫癜(ITP)患者外周血淋巴细胞CD28、CTLA-4(CD152)、B7-1(CD80)及B7-2(CD86)的表达及意义。方法:采用免疫荧光标记和流式细胞术检测41例ITP患者和40例健康对照者外周血CD3+CD28+细胞、CD3+CD152+细胞、CD80+CD19+细胞和CD86+CD19+细胞分别占淋巴细胞的比例及血小板表面相关抗体水平,进行2组对比、分析。结果:与正常对照组相比,急性ITP患者外周血CD3+CD28+细胞和CD3+CD152+细胞差异无统计学意义(P0.05),CD80+CD19+细胞增多(P0.05),CD86+CD19+细胞显著增多(P0.01),慢性ITP患者CD86+CD19+细胞增多(P0.05);急性ITP患者外周血CD86+CD19+细胞较慢性ITP患者增多(P0.05);与正常对照组相比,急性ITP患者PAIg's、PAIgG和PAIgM水平显著增高,慢性ITP患者PAIgG水平增高;CD80、CD86表达与PAIgG水平之间存在显著的相关性(均P0.01)。结论:ITP患者外周血B淋巴细胞上CD86和CD80表达均异常,可能与其发病相关。
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| 关 键 词： | 血小板减少性紫癜 特发性 CD28 CTLA-4 B7 |
Expression and significance of CD28/CTLA-4:B7 in peripheral blood lymphocytes of patients with idiopathic thrombocytopenic purpura |
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| ZHANG Shenghui BI Laixi HAN Yixiang WU Jianbo HU Xiaoxia.Expression and significance of CD28/CTLA-4:B7 in peripheral blood lymphocytes of patients with idiopathic thrombocytopenic purpura[J].Journal of Clinical Hematology,2010(2). |
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| Authors: | ZHANG Shenghui BI Laixi HAN Yixiang WU Jianbo HU Xiaoxia |
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| Institution: | 1Laboratory of Internal Medicine/a>;First Affiliated Hospital of Wenzhou Medical College/a>;Wenzhou/a>;325000/a>;China/a>;2Department of Hematology/a>;First Affiliated Hospital of Wenzhou Medical College |
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| Abstract: | Objective:To investigate the expression and significance of co-stimulatory molecules CD28,cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4,CD152),B7-1 (CD80) and B7-2 (CD86) in lymphocytes from patients with idiopathic thrombocytopenic purpura (ITP).Method:Blood samples were collected from 41 ITP patients and 40 healthy controls. The percentages of CD3+CD28+,CD3+CD152+,CD80+CD19+ and CD86+CD19+ cells on lymphocytes were determined with flow cytometry and monoclonal antibodies technology. Platelet-associa... |
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| Keywords: | idiopathic thrombocytopenic purpura CD28 CTLA-4 B7 |
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