| 阿尔茨海默病的非匹配负波的实验研究 |
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| 引用本文： | 马顺天,楼美珍,王晓玲,李新平,楼兰香,骆杭丽,王兰青. 阿尔茨海默病的非匹配负波的实验研究[J]. 中国组织工程研究与临床康复, 2003, 7(7): 1102-1103 |
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| 作者姓名： | 马顺天 楼美珍 王晓玲 李新平 楼兰香 骆杭丽 王兰青 |
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| 作者单位： | 浙江省义乌市中心医院神经内科,浙江省义乌市,322000 |
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| 摘 要： | 目的非匹配负波可反映大脑皮层早期预处理的指标,探讨阿尔茨海默病(Alzheimerdisease,AD)患者非匹配负波(mismatchnegativity,MMN)的变异特征。方法应用美国NicoletSpirit脑诱发电位仪,对34例AD患者和36例健康老人的MMN作了检测。结果AD组波形不规则,MMN-Ⅰ型(延迟型)尤甚。与正常老人组相比,AD组MMN潜伏期延迟(P<0.05),本组患者P300潜伏期虽也有延长,但差异未达显著性(P>0.05)。与正常老人组比较,AD组MMN波幅以及P300波幅均同时降低,差异均有极显著性意义(均P<0.01)。结论初步认为MMN是反映AD患者认知功能的一种脑电生理检测工具。
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| 关 键 词： | 阿尔茨海默病 诱发电位 事件诱发电位 P300 认知 |
| 文章编号： | 1671-5926(2003)07-1102-02 |
| 修稿时间： | 2003-01-15 |
Experimental study of mismatch negativity in patients with Alzheimer disease |
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| Ma Shuntian,Lou Meizhen,Wang Xiaol ing,Li Xinping,Lou Lanxiang,Luo Hangli,Wang Lanqing. Experimental study of mismatch negativity in patients with Alzheimer disease[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2003, 7(7): 1102-1103 |
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| Authors: | Ma Shuntian Lou Meizhen Wang Xiaol ing Li Xinping Lou Lanxiang Luo Hangli Wang Lanqing |
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| Affiliation: | Ma Shuntian,Lou Meizhen,Wang Xiaol ing,Li Xinping,Lou Lanxiang,Luo Hangli,Wang Lanqing.Department of Neurology,People' s Hospital of Yi-wu,Yiwu 322000,Zhejiang Province,China |
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| Abstract: | Aim In order to investigate the charactc ristics of mismatch negativity(MMN)of patients with Alzheimer disease,this study was made.Methods The MMN was elicited from 34patients with Alzheimer disease and 36normally age-matched controls by using a Nicolet Spirit BE P Instrument.Results AD patients presented irregular MMN waveform ,es-pecially MMN-I type.Compared with AD group,AD group showed prolonged latency(P<0.05)and decreased amplitude(P<0.01).Conclusion The MMN is of value in assessing the cognitive dysfunctions of AD patients. |
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| Keywords: | Alzheimer disease evoked potentials event-related p o-tentials P300 cognitive |
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