| BMP-2对体外培养人牙髓细胞TIMP-1、TIMP-2表达的影响 |
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| 引用本文： | 林媛,沙鑫家,吴补领,高杰,臧晓霞. BMP-2对体外培养人牙髓细胞TIMP-1、TIMP-2表达的影响[J]. 现代口腔医学杂志, 2003, 17(2): 97-99 |
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| 作者姓名： | 林媛 沙鑫家 吴补领 高杰 臧晓霞 |
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| 作者单位： | 710032,西安,第四军医大学口腔医学院 |
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| 基金项目： | 高等学校骨干教师资助计划资助 |
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| 摘 要： | 目的：观察BMP－2对HDPF表达TIMP－1、TIMP－2的影响。方法：用4ng/ml、40ng/ml、400ng/ml BMP-2分别作用于HDPF 2d，利用免疫组化和图像分析法法半定量观察BMP－2对HDPF表达TIMP－1、TIMP－1、TIMP－2表达显著增强，结论：BMP－2通过改变HDPF表达TIMP－1、－2的量来影响胶原的代谢。
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| 关 键 词： | 基质金属蛋白酶抑制 人牙髓成纤维细胞 免疫组织化学 |
| 修稿时间： | 2002-04-23 |
The effect of BMP - 2 on the expression of TIMP - 1, TIMP - 2 in HDPF in vitro |
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| LIN Yuan,SHA Xinjia,WU Bulin,et al.. The effect of BMP - 2 on the expression of TIMP - 1, TIMP - 2 in HDPF in vitro[J]. Journal of Modern Stomatology, 2003, 17(2): 97-99 |
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| Authors: | LIN Yuan SHA Xinjia WU Bulin et al. |
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| Affiliation: | LIN Yuan,SHA Xinjia,WU Bulin,et al.College of Stomatology,The Fourth Military Medical University,Xi'an 710032 |
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| Abstract: | ObjectiveTo investigate the influence of BMP-2 on the expression of TIMP-1,TIMP-2 in HDPF.MethodsBMP-2 with the concentration of 4ng/ml,40ng/ml and 400ng/ml were added into HDPF 2d respectively.ResultsThe influence of BMP-2 on the expression of TIMP-1 and TIMP-2 is reliant on dosage.When the concentration of BMP-2 was 400ng/ml,TIMP-1 and TIMP-2 expressions increased greatly.ConclusionBMP-2 can influence the metabolization of collagen by changing the expression of TIMP-1 and TIMP-2. |
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| Keywords: | Tissue inhibitors of metalloproteinaseHuman dental pulp fibroblastImmunohistochemistry |
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