博乐欣与西酞普兰治疗抑郁症对照研究

目的：探讨博乐欣与西酞普兰治疗抑郁症的疗效与安全性。方法：86例抑郁症患者随机分为2组,分别给予博乐欣与西酞普兰治疗,疗程6周。采用汉密尔顿抑郁量表（HAMD）评价疗效,同时观察不良反应。结果：治疗3,6周末,两组的HAMD总分均较治疗前显著减低（P〈0.01）;治疗6周末,博乐欣组与西酞普兰组的有效率分别为90.2%,87.5%（P〉0.05）;两组不良反应相当且轻微。结论：博乐欣与西酞普兰治疗抑郁症疗效相当,均安全有效。

A control study of venlafaxine and citalopram in treatment of depression

Objective:To investigate the efficacy and safety of venlafaxine and citalopram in treating the patients with depression.Methods:86 patients with depression were randomly divided into two groups which were treated with venlafaxine and citalopram for 6 weeks respectively.Hamilton Depression Scale(HAMD)was employed to evaluate efficacy,and side effects were observed.Results:The HAMD scores of both groups significantly reduced at weeks 3,6 than pretherapy(P<0.01);At weeks 6,the effective rate of venlafaxine group and citalopram group were 90.2% and 87.5%,respectively(P>0.05);The side effects of both groups were similar and mild.Conclusion:Venlafaxine and citalopram have similar effects in treatment of depression,both are effective and safe.