^131I首次清除分化型甲状腺癌残留组织的影响因素探讨 |
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引用本文: | 敬兴果,程刚.^131I首次清除分化型甲状腺癌残留组织的影响因素探讨[J].内分泌外科杂志,2009,3(3):167-169. |
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作者姓名: | 敬兴果 程刚 |
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作者单位: | 重庆医科大学附属第一医院核医学科,重庆,400016 |
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摘 要: | 目的观察^131I首次“清甲”的疗效及分析其影响因素。方法确诊分化型甲状腺癌(DTC)患者经手术治疗后行^131I治疗,然后按手术方式、术后治疗时间^131I的剂量进行分类,观察首次“清甲”的疗效。结果“清甲”成功率:甲状腺全切88.5%,次全切除44.4%;“清甲”时间术后1~2个月92.7%,1年以上50.0%;^131I剂量2.96GBq为47.6%,4.44GBq为82.8%。结论DTC治疗应以甲状腺全切及颈淋巴结清扫为首选治疗方式,术后1~2个月为^131I“清甲”最佳时机,首次“清甲”^131I剂量以4.44GBq(120mci)为宜。
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关 键 词: | 分化型甲状腺癌术后 ^131I碘清除 |
The effect factors of first iodine-131 ablation of thyroid remnants in patients with differentiated thyroid cancer |
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Authors: | JING Xing-guo CHENG Gang |
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Institution: | .( Department of Nuclear Medicirve , the First Affiliated Hospital, Chongqing Medical University, Chongqing 40016, China) |
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Abstract: | Objective To observe the effect of the first iodine-131 ablation of thyroid remnants in pa-tients with differentiated thyroid cancer (DTC) and discuss factors that may be influential in the treatment. Meth-ods All DTC patients confirmed by pathology received iodine-131 therapy after necessary preparation. Accord-ing different operation procedures, time interval between operation and iodine-131 treatment and dose of iodine - 131, the patients were divided into different groups. Therapy effects were observed in different groups. Results Ablation successful rate was 88.5% in total thyroidectomy group, compared with 44.4% in subtotal thyroidecto-my group. 92.7% ablation rate was seen in the group of I-2 months time interval between operation and iodine - 131 treatment, while in the group of over 1 year time interval, only 50% ablationrate was achieved. Ablation successful rate was 47.6% in the group of low dose of iodine-131 (2.96GBq), compared with 82.8% in the high dose group (4.44GBq). Conclusions Total thyroidectomy and cervical lymph nodes dissection should be recommended for the patients with DTC. The better interval time between operation and iodine-131 ablation thy-roid remnants is 1~2 months. The high dose of iodine-131 shows better result than low dose of iodine-131 treatment. |
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Keywords: | Differentiated thyroid cancer (DTC) Iodine-131 ablation |
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