Determination of 3 beta-hydroxylated bile acids in human serum and liver tissue |
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| Authors: | T Nagakura H Suzuki Y Miyazaki M Otsuki J Goto T Nambara T Toyota |
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| Affiliation: | Third Department of Internal Medicine, Tohoku University School of Medicine, Sendai. |
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| Abstract: | 3 beta, 7 alpha-Dihydroxy-5 beta-cholanoic acid (3 beta, 7 alpha-diOH) was detected in serum of 3 patients with intrahepatic cholestasis. 3 beta, 7 beta-dihydroxy-5 beta-cholanoic acid (3 beta, 7 beta-diOH) appeared in serum of those patients after treatment with ursodeoxycholic acid (UDC). These bile acids were also detected in only unconjugated fractions of serum of another 7 patients with chronic liver diseases, but not in liver tissue of them. The liver does not seem to from these bile acids itself because they were absent in liver tissue. |
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