Deoxycholate induces COX-2 expression via Erk1/2-, p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells |
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| Authors: | Eileen Looby Mohamed MM Abdel-Latif Veronica Athié-Morales Shane Duggan Aideen Long Dermot Kelleher |
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| Affiliation: | (1) Department of Clinical Medicine and Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland;(2) Department of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland |
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| Abstract: | Background The progression from Barrett's metaplasia to adenocarcinoma is associated with the acquirement of an apoptosis-resistant phenotype. The bile acid deoxycholate (DCA) has been proposed to play an important role in the development of esophageal adenocarcinoma, but the precise molecular mechanisms remain undefined. The aim of this study was to investigate DCA-stimulated COX-2 signaling pathways and their possible contribution to deregulated cell survival and apoptosis in esophageal adenocarcinoma cells. |
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