Changes in vertebral bone marrow fat and bone mass after gastric bypass surgery: A pilot study |
| |
| Affiliation: | 1. Department of Medicine, University of California, San Francisco, CA, USA;2. Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA;3. Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA;4. Department of Surgery, University of California, San Francisco, CA, USA;5. Medical Service, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA;6. Surgical Service, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA;1. Department of Prosthodontics Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, PR China;2. Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong 510055, PR China;3. Shanghai Tenth People''s Hospital, Tongji University School of Medicine, Shanghai 200072, PR China;4. Guangdong No. 2 Provincial People''s Hospital, Guangzhou, Guangdong 510317, PR China;5. Guangzhou Hospital of Integrated Traditional and West Medicine, Guangzhou, Guangdong 510800, PR China;6. Huizhou Stomatological Hospital Zhong Kai Branch, Huizhou, Guangdong 516006, PR China;1. Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic;2. Clinic for Sports Medicine, Lucerne Cantonal Hospital, Lucerne, Switzerland;3. Exercise Physiology Lab, Institute of Human Movement Sciences, ETH Zurich, Zurich, Switzerland;4. Department of Statistics, Faculty of Mathematics and Physics, Charles University in Prague, Prague, Czech Republic;1. Department of Human Biosciences, La Trobe University, Bundoora 3086, Australia;2. Department of Physiology, The University of Melbourne, Parkville 3010, Australia;3. Department of Medicine, The University of Melbourne, Parkville 3050, Australia;4. Bone and Mineral Medicine, Royal Melbourne Hospital, Parkville 3050, Australia;1. Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, Kobe, Japan;2. Product Research Department, Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd., Shizuoka, Japan;3. Tokyo Animal & Diet Dept., CLEA Japan, Inc., Tokyo, Japan;4. Division of Nephrology, Endocrinology, and Metabolism, Department of Medicine, Tokai University School of Medicine, Isehara, Japan |
| |
| Abstract: | Bone marrow fat may serve a metabolic role distinct from other fat depots, and it may be altered by metabolic conditions including diabetes. Caloric restriction paradoxically increases marrow fat in mice, and women with anorexia nervosa have high marrow fat. The longitudinal effect of weight loss on marrow fat in humans is unknown. We hypothesized that marrow fat increases after Roux-en-Y gastric bypass (RYGB) surgery, as total body fat decreases. In a pilot study of 11 morbidly obese women (6 diabetic, 5 nondiabetic), we measured vertebral marrow fat content (percentage fat fraction) before and 6 months after RYGB using magnetic resonance spectroscopy. Total body fat mass declined in all participants (mean ± SD decline 19.1 ± 6.1 kg or 36.5% ± 10.9%, p < 0.001). Areal bone mineral density (BMD) decreased by 5.2% ± 3.5% and 4.1% ± 2.6% at the femoral neck and total hip, respectively, and volumetric BMD decreased at the spine by 7.4% ± 2.8% (p < 0.001 for all). Effects of RYGB on marrow fat differed by diabetes status (adjusted p = 0.04). There was little mean change in marrow fat in nondiabetic women (mean + 0.9%, 95% CI − 10.0 to + 11.7%, p = 0.84). In contrast, marrow fat decreased in diabetic women (− 7.5%, 95% CI − 15.2 to + 0.1%, p = 0.05). Changes in total body fat mass and marrow fat were inversely correlated among nondiabetic (r = − 0.96, p = 0.01) but not diabetic (r = 0.52, p = 0.29) participants. In conclusion, among those without diabetes, marrow fat is maintained on average after RYGB, despite dramatic declines in overall fat mass. Among those with diabetes, RYGB may reduce marrow fat. Thus, future studies of marrow fat should take diabetes status into account. Marrow fat may have unique metabolic behavior compared with other fat depots. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
