Thickened saliva after effective management of drooling with botulinum toxin A |
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| Authors: | CORRIE E ERASMUS KAREN VAN HULST FRANK JA VAN DEN HOOGEN JACQUES VAN LIMBEEK NEL ROELEVELD ENNO CI VEERMAN JAN J ROTTEVEEL PETER H JONGERIUS |
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| Institution: | 1. Department of Paediatric Neurology, Radboud University Nijmegen Medical Centre/Donders Institute for Brain, Cognition and Behaviour, the Netherlands;2. Department of Rehabilitation, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands;3. Department of Otorhinolaryngology, Head and Neck Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands;4. Department of Research, Development and Education, Sint Maartenskliniek, Nijmegen, the Netherlands;5. Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands;6. Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, the Netherlands;7. Department of Rehabilitation, Sint Maartenskliniek, Nijmegen, the Netherlands. |
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| Abstract: | Aim The aim of this study was to evaluate the rheological properties of saliva after submandibular botulinum toxin type A (BoNT‐A) injections. Method We enrolled 15 children (11 males and six females; age range 3–17y, mean age 9y 10mo) diagnosed with spastic (n=9) or dyskinetic (n=6) quadriplegic cerebral palsy (CP); Gross Motor Function Classification System level IV or V; and two children with intellectual disability (IQ <70) who experienced moderate to severe drooling. Salivary flow rate and drooling quotient were measured at baseline and at different times after BoNT‐A injections up to 24 weeks. The mucin concentration of saliva was analysed before and after BoNT‐A treatment. Results Both submandibular salivary flow rate (baseline 0.38mL/min; 24wks after injection 0.26mL/min) and drooling quotient (baseline 42.5%; 24wks 28.80%) were substantially reduced, with a concomitant increase in mucin concentration within 8 weeks after BoNT‐A injection (from 0.612 to 1.830U/mL). The parents of nine children observed thickened saliva. Swallowing and chewing were problematic in seven children. Two of these children needed treatment with mucolytics because of pooling of thickened saliva in the throat. Interpretation When making decisions about the use of BoNT‐A, the risk of problems with masticatory and swallowing functions as a result of thickening of saliva after BoNT‐A treatment should be taken into account. |
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