The effects of beta-2 adrenergic agonist and antagonist on human bone metabolism: A randomized controlled trial |
| |
| Institution: | 1. Dept. of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands;2. Dept. of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands;3. Dept. of Clinical Chemistry, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands;4. Dept. of Clinical Chemistry, Endocrine Laboratory, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands;5. Dept. of Internal Medicine, Endocrine Section, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands;1. Faculty of Dentistry, McGill University, Montreal, Quebec, Canada;2. Department of Mining and Materials, McGill University, Montreal, Quebec, Canada;3. Department of Chemical Engineering, École Polytechnique, Montreal, Quebec, Canada;4. Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada;5. Department of Chemistry, Central Michigan University, Mount Pleasant, MI, USA;6. Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA;1. Hokkaido University, Department of Orthopedic Surgery, School of Medicine, Sapporo, Japan;2. Hokkaido University, Laboratory of Molecular Cell Dynamics, Faculty of Advanced Life Science, Sapporo, Japan;3. Hokkaido University, Department of Biochemistry, School of Medicine, Sapporo, Japan;4. Institute of Biological Chemistry, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 11529, Taiwan;1. Institute of Orthopaedics and Traumatology, Zhejiang Chinese Medical University, Zhejiang, China;2. Key Laboratory of Hormones and Development (Ministry of Health), Metabolic Diseases Hospital & Institute of Endocrinology, Tianjin Medical University, Tianjin 300070, China;3. Department of Biochemistry, Rush University Medical Center, Chicago, IL, USA;4. Liaoning University of Traditional Chinese Medicine, Liaoning, China;5. Amgen Inc., Thousand Oaks, CA, USA;6. Department of Orthopaedics, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang, China |
| |
| Abstract: | PurposeGenetic knockout or pharmacological inhibition of the beta-2 adrenergic receptor (B2AR) increased bone mass, whereas stimulation decreased bone mass in rodents. In humans, observational studies support sympathetic nervous system regulation of bone metabolism, but intervention studies are lacking. We aimed to determine the effects of a selective beta-2 adrenergic agonist and non-selective antagonist on human bone metabolism.Methods32 healthy postmenopausal women were included in a randomized controlled trial conducted in the Academic Medical Center Amsterdam. Participants were randomized to receive treatment with 17-β estradiol 2 mg/day; 17-β estradiol 2 mg/day and terbutaline 5 mg/day (selective B2AR agonist); propranolol 80 mg/day (non-selective B-AR antagonist); or no treatment during 12 weeks. Main outcome measure was the change in serum concentrations of procollagen type I N propeptide (P1NP) and C-terminal crosslinking telopeptides of collagen type I (CTx) as markers of bone formation and resorption after 12 weeks compared between the treatment groups. Data were analyzed with mixed model analysis.Results17-β estradiol decreased bone turnover compared to control (P1NP p < 0.001, CTx p = 0.003), but terbutaline combined with 17-β estradiol failed to increase bone turnover compared to 17-β estradiol alone (P1NP p = 0.135, CTx p = 0.406). Propranolol did not affect bone turnover compared to control (P1NP p = 0.709, CTx p = 0.981).ConclusionSelective beta-2 adrenergic agonists and non-selective beta-antagonists do not affect human bone turnover although we cannot exclude small changes below the detection limit of this study. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
