Objectively measured physical activity is associated with parameters of bone in 70-year-old men and women |
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| Institution: | 1. Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden;2. Department of Community Medicine and Rehabilitation, Sports Medicine, Umeå University, Umeå, Sweden;3. Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, Umeå University, Umeå, Sweden;1. Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA;2. Drexel University, Philadelphia, PA, USA;3. Department of Medicine, Rutgers-Robert Wood Johnson University Hospital, USA;1. INSERM U1153, Paris Descartes University, Rheumatology Department, Cochin Hospital, Paris, France;2. Rheumatology Department Lariboisière Hospital, Paris, France;1. Centre for Children''s Bone Health, The Children''s Hospital at Westmead, Westmead, NSW, Australia;2. Discipline of Paediatrics and Child Health, Faculty of Medicine, University of Sydney, Sydney, NSW, Australia;3. Department of Reconstructive Sciences, School of Dental Medicine, UConn Health, Farmington, CT, USA;1. Department of Orthopaedics and Rehabilitation, Yale University, New Haven, CT 06520, USA;2. Department of Internal Medicine, Yale University, New Haven, CT 06520, USA;1. Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Rasht, Iran;2. Orthopaedic Surgeon, Poorsina Hospital, Rasht, Iran;1. Departments of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan;2. Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan;3. Centre for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan;4. Core Laboratory for Phenomics and Diagnostics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan;5. Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Kaohsiung, Taiwan |
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| Abstract: | As the world's population ages, the occurrence of osteoporosis-related fractures is projected to increase. Low areal bone mineral density (aBMD), a well-known risk factor for fractures, may be influenced by physical activity (PA). In this cross-sectional study, we aimed to investigate potential associations between objective measures of PA and bone properties, in a population-based cohort of 1228 70-year-old men and women. We measured volumetric BMD (vBMD, mg/cm3) together with cross-sectional area (CSA, mm2) by peripheral quantitative computed tomography at sites located 4% and 66% in the distal–proximal trajectory at the tibia and radius. We also measured aBMD (g/cm2) by dual energy X-ray absorptiometry at the femoral neck, lumbar spine (L1–L4) and radius. Participants wore triaxial accelerometers for 7 consecutive days to obtain objective estimates of PA. The intensity of the objective PA was divided into light (100–1951 counts/min CPM]), moderate (1952–5724 cpm) and vigorous (≥ 5725 cpm). Maximal accelerations for the anterior–posterior (z), medio-lateral (x), and vertical (y) axes were also separately assessed. Associations were investigated using bivariate correlations and multiple linear regression, adjusted for height, weight and sex. Vigorous PA showed the strongest association with femoral neck aBMD (β = 0.09, p < 0.001), while both moderate and vigorous PAs were associated with cortical area and trabecular vBMD in the weight-bearing tibia (all p < 0.05). Peak vertical accelerations were associated significantly with cortical area (β = 0.09, p < 0.001) and trabecular vBMD (β = 0.09, p = 0.001) of the tibia, whereas peak anterior–posterior accelerations showed no correlation with these properties. No positive association was found between objectively measured PA and bone parameters of the radius. In conclusion, vertical accelerations and moderate to vigorous PA independently predict bone properties, especially in the weight-bearing tibia, in 70-year-old men and women. |
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