| RNF180在胃癌中的研究进展 |
| |
| 作者姓名： | 张雅婷 魏育才 李玉民 |
| |
| 作者单位： | 兰州大学第二临床医学院,甘肃 兰州 730000 ；甘肃省消化系肿瘤重点实验室,甘肃 兰州 730030 |
| |
| 基金项目： | 国家自然基金项目 (31770537)；甘肃省科技重大专项 (20ZD7FA003)；甘肃省教育厅项目 (2021jyjbgs-02)；甘肃省青年科技基金项目(20JR5RA321) |
| |
| 摘 要： | RNF180是具有泛素连接酶活性的一类环指蛋白,可通过参与泛素-蛋白酶体系统影响细胞增殖、分化及凋亡等多种生理过程。研究表明,RNF180在肿瘤中多呈低表达,可抑制胃癌细胞的增殖侵袭,影响胃癌淋巴结转移及预后。RNF180的启动子甲基化引起的基因表达沉默是导致RNF180蛋白在肿瘤中低表达的主要原因,重要甲基化位点与癌前病变、胃癌淋巴结转移及患者预后相关。故RNF180具有成为胃癌肿瘤生物标志物的潜力。
|
| 关 键 词： | RNF180 胃癌 泛素 DNA甲基化 |
Research progress of RNF180 in gastric cancer |
| |
| Authors: | Zhang Yating Wei Yucai Li Yumin |
| |
| Institution: | (Second Clinical Medical College of Lanzhou University,Lanzhou 730000,Gansu,China;Gansu Provincial Key Laboratory of Gastrointestinal Tumors,Lanzhou 730030,Gansu,China) |
| |
| Abstract: | RNF180 is a type of ring finger protein with ubiquitin ligase activity, which can affect various physiological processes such as cell proliferation, differentiation and apoptosis by participating in the ubiquitin-proteasome system. Studies have shown that RNF180 is mostly low-expressed in tumors, which can inhibit the proliferation and invasion of gastric cancer cells, and affect the lymph node metastasis and prognosis of gastric cancer. The gene expression silencing caused by the methylation of the promoter of RNF180 is the main reason for the low expression of RNF180 protein in tumors. Important methylation sites are related to precancerous lesions, lymph node metastasis of gastric cancer and patient prognosis. Therefore, RNF180 has the potential to become a biomarker of gastric cancer tumors. |
| |
| Keywords: | RNF180 Gastric cancer Ubiquitin DNA methylation |
| 本文献已被 维普 等数据库收录！ |
| 点击此处可从《》浏览原始摘要信息 |
| 点击此处可从《》下载免费的PDF全文 |
|
