山药决明子挂面对血脂异常大鼠模型血脂及抗氧化的影响

目的探讨山药决明子挂面对血脂异常大鼠模型血脂及抗氧化的影响。方法48只SD大鼠分为正常对照组(8只)和模型组(40只),模型组大鼠经4周高脂饮食喂养后建立血脂异常大鼠模型,采用随机数字法分为模型组、阿托伐他汀阳性对照组(10 mg/kg/d)、山药决明子挂面低、中、高剂量组,每组8只。干预5周后测定血清总甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、肝体比、肝脏胆固醇(TC)、甘油三酯(TG)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)和总抗氧化能力(T-AOC)。结果与模型组相比,中剂量山药决明子挂面组大鼠血清TC、肝脏TC、TG水平分别下降14.76%、23.75%、39.69%(P<0.05),低、中、高剂量组血清TG、LDL-C水平均有所下降(P<0.05),低剂量组肝脏SOD、GSH-Px、T-AOC分别升高24.09%、26.90%、290.24%(P<0.05)。结论山药决明子挂面能降低血脂异常大鼠血脂水平,提高抗氧化水平,对辅助治疗血脂异常及抗氧化有一定的应用价值。

Effects of yam and cassia seed vermicelli on blood lipid metabolism and antioxidation in dyslipidemia rats

Objective To explore the effects of yam and cassia seed vermicelli on blood lipid metabolism and antioxidation in dyslipidemia rats.Methods Forty-eight SD rats were divided into model group(40 rats)and control group(8 rats).The rats in the model group were fed with high-fat diet for 4 weeks to establish a dyslipidemia rat model.40 rats were randomly divided into model group,atorvastatin positive control group(10mg/kg/d),yam cassia seed vermicelli low,medium and high dose groups by random number method,with 8 rats in each group.After 5 weeks of intervention,a series of serum lipids index[total triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)],liver body ratio,liver TG,TC,superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),malondialdehyde(MDA)and total antioxidant capacity(T-AOC)were measured.Results Compared to the model group,TC of serum,TC and TG of liver decreased by 14.76%,23.75% and 39.69% in the medium dose group respectively,while SOD,GSH PX and T-AOC increased by 24.09%,26.90% and 290.24% in the low dose group,respectively(P<0.05).The TG and LDL-C level of Serum were decreased in low,medium and high dose groups(P<0.05).Conclusion Yam and cassia seed vermicelli can reduce the blood lipid level and improve the antioxidant level in dyslipidemia rats.It has a certain application value in the adjuvant treatment of dyslipidemia and antioxidant.