寻常型银屑病皮肤及甲襞微循环变化分析

目的：研究寻常型银屑病患者皮损、非皮损、甲襞微循环血流灌注变化情况。方法：利用激光多普勒散斑血流仪检测88例寻常型银屑病患者胫前皮损、非皮损与100名对照胫前正中及两组指尖血流灌注绝对值。结果：患者皮损、非皮损与正常对照皮肤微循环灌注绝对值分别为（319.96±124.65）BPU,（100.87±19.74）BPU和（60.10±13.90） BPU,三组比较差异有统计学意义（均P＜0.05）。甲银屑病指尖微循环灌注值为（406.31±64.01BPU）,高于无甲受累患者的（270.13±69.41） BPU和对照组的（361.15±113.70） BPU,差异有统计学意义（P＜0.05）;皮损微循环灌注绝对值与PASI评分之间呈正相关（r=0.744）。结论：寻常型银屑病患者皮肤及甲襞微循环血流灌注异常,皮损部位灌注值与病情严重程度相关。

The changes of microcirculation in the skin lesions and nail fold in the patients with psoriasis vulgaris

Objectives: To assess the changes of microcirculation in the skin and nail fold in the patients with psoriasis vulgaris. Methods: The blood perfusion scores of normal skin or lesions on pretibia and nail fold in 88 patients with psoriasis vulgaris and 100 controls were detected by Laser doppler speckle flowmeter. Results: The scores of skin lesion and normal skin from the patients and controls were (319.96±124.65) BPU, (100.87±19.74) BPU and (60.10±13.90）BPU respectively, with significant differences (Ps<0.05). The score of psoriasis nail fold was (406.31±64.01) BPU, which was higher than that of the normal nail fold in the patients (270.13±69.41) BPU and controls (361.15±113.701) BPU. The blood perfusion score of lesions was strongly positively correlated to PASI scores (P<0.05). Conclusion: The score of microcirculation perfusion in skin and nail fold in the patients with psoriasis vulgaris are higher than normal. The score of microcirculation perfusion of lesion is associated with the severity of the disease.