5490例性病门诊患者HPV检测结果分析

目的：了解山东地区人乳头瘤病毒(HPV)感染情况,为HPV的防治提供依据。方法：采用实时荧光定量PCR方法(FQ-PCR)对2012年8月至2016年8月期间就诊于山东省皮肤病医院性病门诊的5490例患者进行LR-HPV(6,11型)和HR-HPV (16、18、31、33、45、52、56、58型)检测。 结果：HPV（6,11型）阳性2016例(36.72%) ,其中女753例（32.81%）,男1263例（39.53%）,男女阳性率差异有统计学意义（P＜0.01）;HR-HPV阳性1715例(31.24%),其中女925例（40.31%）,男790例（24.73%）,男女阳性率差异有统计学意义（P＜0.01）;HPV（6,11 型）合并HR-HPV阳性768例(13.99%),其中女358例（15.6%）,男410例（12.83%）,男女阳性率差异无统计学意义（P >0.05）。女性HPV（6,11 型）及HR-HPV 感染率高峰出现在20岁以下及50岁以上,不同年龄段女性HPV感染率均有显著差异（P＜0.05）,而不同年龄段男性HPV感染率均无显著差异。结论：山东地区男性LR-HPV（6,11型）感染率明显高于女性,而女性HR-HPV的感染率高于男性;山东地区女性HPV感染率随着年龄的变化成“U”型分布,男性HPV感染率与年龄无关。

Analysis of HPV detection in 5490 venereal outpatients in Shandong district

Objective: To investigate the infection of human?papilloma virus (HPV) in Shandong district to provide prevention of HPV. Method: The infections of LR-HPV (6,11) and HR-HPV (16, 18, 31, 33, 45, 52, 56 and 58 type) were detected by real-time fluorescent quantitative PCR (FQ-PCR) among 5490 outpatients in our institute. Result: Two thousand and sixteen patients were positive for LR-HPV, including 753 female (32.81%) and 1263 male (39.53%), and there was a significant difference in positivity rate between male and female (P＜0.01). Seventeen hundred and fifteen patients were positive for HR-HPV, including 925 female (40.31%) and 790 male (24.73%), and there was a significant difference in the positivity rate between male and female (P＜0.01). Seven hundred and six eight patients were positive for LR-HPV and HR-HPV, including 358 (15.6%) female and 410 male (12.83%), and there was no significant difference in the positivity rate between male and female (P>0.01). The peak age of female patients was under 20-year-old and above 50-year-old. There were significant differences between different age groups (P<0.05). There was no significant difference between different age groups in male (P>0.05). Conclusion: The infection rate of LR-HPV in male patients is significant higher than that in female, while the infection rate of HR-HPV in female patients is higher than that in male. The age distribution of female patients is in a pattern of U shape, while there was no association between the HPV infection rate and age in male patients.